ArticleProceedings of the National Academy of Sciences of the United States of America1990
A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 62 citations in OpenAlex.
- ProTide generated long-acting abacavir nanoformulations.Chemical communications (Cambridge, England) · 2018Article
- High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12.American journal of human genetics · 2000Article
- The natural killer cell serine protease gene Lmet1 maps to mouse chromosome 10.Immunogenetics · 1995Article
- Linkage of autosomal recessive lamellar ichthyosis to chromosome 14q.American journal of human genetics · 1994Article
- The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3.Immunogenetics · 1994Article
- Article
- Neutrophil-derived Oxidants and Proteinases as Immunomodulatory Mediators in Inflammation.Mediators of inflammation · 1994Article
- Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Confirmation of the human cathepsin B gene (CTSB) assignment to chromosome 8.Human genetics · 1992Article
- Transcription of two cytotoxic cell protease genes is under the control of different regulatory elements.Nucleic acids research · 1991Article
- Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes.Molecular and cellular biology · 1990Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The chymotrypsin-like family of serine protease genes includes several members that are expressed exclusively in subsets of hematopoietic cells. For example, human neutrophil elastase and cathepsin G are expressed only in myelomonocytic precursors, and cytotoxic-T-cell serine proteases are found only in cytotoxic lymphocytes. We have used a cathepsin G cDNA probe to clone two cathepsin G-like genes (designated CGL-1 and CGL-2) from a human genomic library. We have determined that CGL-1 is identical to a previously identified gene (known as CCPI, CTLA I, or cytotoxic serine protease B) that is expressed only in activated cytotoxic T lymphocytes. We show here that cathepsin G, CGL-1, and CGL-2 are linked on an approximately 50-kilobase locus found on human chromosome 14 at band q11.2. This gene cluster maps to the same chromosomal band as the alpha and delta T-cell receptor genes; this region is involved in most chromosomal translocations and inversions that are specifically associated with T-cell malignancies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.