ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2012
Optimal diffusion coefficient estimation in single-particle tracking.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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Who cites it
120 citing papers in PubMed.
- Genetically inducible coordinators of cytokine signaling pathways for interrogating T cell motility.bioRxiv : the preprint server for biology · 2026Article
- Review of Machine Learning for Single-Particle Tracking: Methods, Challenges, and Biophysical Insights.Chemical & biomedical imaging · 2026Review
- ER tethering and active transport govern condensate diffusion during hyperosmotic stress.Genome biology · 2026Article
- Multicolor Quantum Dot Tracking Uncovers Phenotypic Rescue of DAT A559V Aberrant Diffusion Upon D2R Antagonism.ACS chemical neuroscience · 2026Article
- Surface-Tethering Enhances Precision in Measuring Diffusion Within 3D Protein Condensates.Journal of molecular biology · 2026Article
- Direct microsecond wide-field single-molecule tracking and super-resolution mapping via CCD vertical shift.Nature communications · 2025Article
- Parameter optimization for MINFLUX microscopy enabled single particle tracking.Communications biology · 2025Article
- High-Speed Interferometric Scattering Tracking Microscopy of Compartmentalized Lipid Diffusion in Living Cells.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Practical considerations for accurate estimation of diffusion parameters from single-particle tracking in living cells.The Journal of chemical physics · 2025Article
- Clustering within a single-component biomolecular condensate.bioRxiv : the preprint server for biology · 2025Article
- Article
- Autoregulation of the real-time kinetics of the human mitochondrial replicative helicase.Nature communications · 2025Article
- Surface-Tethering Enhances Precision in Measuring Diffusion Within 3D Protein Condensates.bioRxiv : the preprint server for biology · 2025Article
- Practical considerations for accurate estimation of diffusion parameters from single-particle tracking in living cells.bioRxiv : the preprint server for biology · 2025Article
- Transport in the brain studied withNeurophotonics · 2025Review
- 3D nanoprinted fiber-interfaced hollow-core waveguides for high-accuracy nanoparticle tracking analysis.Light, science & applications · 2025Article
- Fiber-assisted nanoparticle tracking analysis meets nanorheology: a novel approach for probing viscoelastic properties at the nanoscale.Nanophotonics (Berlin, Germany) · 2025Article
- Synthesis and Characterization of a Novel Photocleavable Fluorescent Dye Dyad for Diffusion Imaging.Chemical & biomedical imaging · 2025Article
- The relationship between nanoscale genome organization and gene expression in mouse embryonic stem cells during pluripotency transition.Nucleic acids research · 2024Article
- Capillary-assisted flat-field formation: a platform for advancing nanoparticle tracking analysis in an integrated on-chip optofluidic environment.Nanophotonics (Berlin, Germany) · 2024Article
60 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Single-particle tracking is increasingly used to extract quantitative parameters on single molecules and their environment, while advances in spatial and temporal resolution of tracking techniques inspire new questions and avenues of investigation. Correspondingly, sophisticated analytical methods are constantly developed to obtain more refined information from measured trajectories. Here we point out some fundamental limitations of these approaches due to the finite length of trajectories, the presence of localization error, and motion blur, focusing on the simplest motion regime of free diffusion in an isotropic medium (Brownian motion). We show that two recently proposed algorithms approach the theoretical limit of diffusion coefficient uncertainty. We discuss the practical performance of the algorithms as well as some important implications of these results for single-particle tracking.
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