ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2012
Curvature sorting of proteins on a cylindrical lipid membrane tether connected to a reservoir.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Biophysical modeling of membrane curvature generation and curvature sensing by the glycocalyx.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Molecular mechanisms of steric pressure generation and membrane remodeling by disordered proteins.Biophysical journal · 2022Article
- A mechanical-thermodynamic model for understanding endocytosis of COVID-19 virus SARS-CoV-2.Proceedings of the Institution of Mechanical Engineers. Part C. Journal of mechanical engineering science · 2022Article
- Membrane Thinning Induces Sorting of Lipids and the Amphipathic Lipid Packing Sensor (ALPS) Protein Motif.Frontiers in physiology · 2020Article
- Excess area dependent scaling behavior of nano-sized membrane tethers.Physical biology · 2018Article
- Hydrodynamics govern the pre-fusion docking time of synaptic vesicles.Journal of the Royal Society, Interface · 2018Article
- Analysis of diffusion in curved surfaces and its application to tubular membranes.Molecular biology of the cell · 2016Article
- Physical basis of some membrane shaping mechanisms.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Review
- When Physics Takes Over: BAR Proteins and Membrane Curvature.Trends in cell biology · 2015Review
- IRSp53 senses negative membrane curvature and phase separates along membrane tubules.Nature communications · 2015Article
- Application of a free-energy-landscape approach to study tension-dependent bilayer tubulation mediated by curvature-inducing proteins.Physical review. E, Statistical, nonlinear, and soft matter physics · 2015Article
- Modeling curvature-dependent subcellular localization of the small sporulation protein SpoVM in Bacillus subtilis.PloS one · 2015Article
- Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins.Physics reports · 2014Article
- Protein-induced membrane curvature alters local membrane tension.Biophysical journal · 2014Article
- Defining the free-energy landscape of curvature-inducing proteins on membrane bilayers.Physical review. E, Statistical, nonlinear, and soft matter physics · 2014Article
- Membrane shape modulates transmembrane protein distribution.Developmental cell · 2014Article
- Bending "on the rocks"--a cocktail of biophysical modules to build endocytic pathways.Cold Spring Harbor perspectives in biology · 2014Article
- FBAR syndapin 1 recognizes and stabilizes highly curved tubular membranes in a concentration dependent manner.Scientific reports · 2013Article
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4 authors.
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Abstract
Membrane curvature of a biological cell is actively involved in various fundamental cell biological functions. It has been discovered that membrane curvature and binding of peripheral membrane proteins follow a symbiotic relationship. The exact mechanism behind this interplay of protein binding and membrane curvature has not yet been properly understood. To improve understanding of the mechanism, we study curvature sorting of proteins in a model system consisting of a tether pulled from a giant unilamellar vesicle using mechanical-thermodynamic models. The concentration of proteins bound to the membrane changes significantly due to curvature. This has also been observed in experiments by other researchers. We also find that there is a phase transition based on protein concentration and we discuss the coexistence of phases and stability of solutions. Furthermore, when sorting is favorable, the increase in protein concentration stabilizes the tether in the sense that less pulling force is required to maintain the tether. A similar mechanism may be in place, when motor proteins pull tethers from donor membranes.
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