Evidence map›Paper›PMID 23003994›Full record

ArticlePhysical review letters2012

Cholesterol mediates membrane curvature during fusion events.

Andrey Ivankin, Ivan Kuzmenko, David Gidalevitz

Abstract read
In one paragraph

Article in Physical review letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. The Role of Cholesterol in M2 Clustering and Viral Budding Explained.Journal of chemical theory and computation · 2025
    Article
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  4. Review
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrey IvankinDepartment of Physics and Center for Molecular Study of Condensed Soft Matter (μCoSM), Illinois Institute of Technology, Chicago, Illinois 60616, USA.
Ivan Kuzmenko
David Gidalevitz

Funding

Antimicrobial Peptides and their Synthetic Mimics - Investigating the Mechanism oR01AI073892 · NIAID · ILLINOIS INSTITUTE OF TECHNOLOGY · PI GIDALEVITZ, DAVID · 2008 to 2011
$1.2M
NIAID NIH HHS R01 AI073892
6 · The paper itself

Abstract

Biomembranes undergo extensive shape changes as they perform vital cellular functions. The mechanisms by which lipids and proteins control membrane curvature remain unclear. We use x-ray reflectivity, grazing incidence x-ray diffraction, and epifluorescence microscopy to study binding of HIV-1 glycoprotein gp41's membrane-bending domain to DPPC/cholesterol monolayers of various compositions at the air-liquid interface. The results offer a new insight into how membrane curvature could be regulated by cholesterol during fusion of the viral lipid envelope and the host cell membranes.

Indexed as

Membrane Fusion1,2-DipalmitoylphosphatidylcholineAmino Acid SequenceCell MembraneCholesterolHIV Envelope Protein gp41Membrane LipidsMembrane ProteinsMicroscopy, FluorescenceMolecular Sequence DataX-Ray Diffraction1,2-DipalmitoylphosphatidylcholineCholesterolgp41 protein, Human immunodeficiency virus 1HIV Envelope Protein gp41Membrane LipidsMembrane Proteins

Identifiers

PMID23003994
PMCPMC8792958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.