ArticleAmerican journal of respiratory cell and molecular biology2013
Sex-specific perinatal nicotine-induced asthma in rat offspring.
Article in American journal of respiratory cell and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Prenatal Household Air Pollution Is Associated with Impaired Infant Lung Function with Sex-Specific Effects. Evidence from GRAPHS, a Cluster Randomized Cookstove Intervention Trial.American journal of respiratory and critical care medicine · 2019Trial
- Prenatal Cannabis and Tobacco: Studies in Animal Models.Advances in experimental medicine and biology · 2026Review
- Nicotinic receptors in airway disease.American journal of physiology. Lung cellular and molecular physiology · 2024Review
- Identifying sensitive windows of prenatal household air pollution on birth weight and infant pneumonia risk to inform future interventions.Environment international · 2023Article
- Preterm Birth, Developmental Smoke/Nicotine Exposure, and Life-Long Pulmonary Sequelae.Children (Basel, Switzerland) · 2023Review
- Perinatal Exposure to Nicotine Alters Sperm RNA Profiles in Rats.Frontiers in endocrinology · 2022Article
- Perinatal exposure to nicotine alters spermatozoal DNA methylation near genes controlling nicotine action.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- MicroRNA-98 reduces nerve growth factor expression in nicotine-induced airway remodeling.The Journal of biological chemistry · 2020Article
- Perinatal nicotine exposure-induced transgenerational asthma: Effects of reexposure in F1 gestation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Prenatal fine particulate exposure and early childhood asthma: Effect of maternal stress and fetal sex.The Journal of allergy and clinical immunology · 2018Article
- Prenatal Nitrate Exposure and Childhood Asthma. Influence of Maternal Prenatal Stress and Fetal Sex.American journal of respiratory and critical care medicine · 2017Article
- The effects of individually ventilated cages on the respiratory systems of male and female Wistar rats from birth until adulthood.Clinics (Sao Paulo, Brazil) · 2017Article
- Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products.Neuroscience and biobehavioral reviews · 2017Review
- Article
- Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.American journal of respiratory cell and molecular biology · 2016Article
- In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model.Birth defects research. Part A, Clinical and molecular teratology · 2015Article
- PPAR-γ agonist rosiglitazone reverses perinatal nicotine exposure-induced asthma in rat offspring.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Inter- and transgenerational epigenetic inheritance: evidence in asthma and COPD?Clinical epigenetics · 2015Article
- Vitamin D supplementation blocks pulmonary structural and functional changes in a rat model of perinatal vitamin D deficiency.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Perinatal nicotine-induced transgenerational asthma.American journal of physiology. Lung cellular and molecular physiology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Recently, we have suggested that down-regulation of homeostatic mesenchymal peroxisome proliferator-activated receptor γ signaling after in utero nicotine exposure might contribute to asthma. Here, we have exploited an in vivo rat model of asthma to determine if the effects of perinatal nicotine exposure on offspring pulmonary function and mesenchymal markers of airway contractility in both tracheal and lung parenchymal tissue are sex specific, and whether the protection afforded by the peroxisome proliferator-activated receptor γ agonist, rosiglitazone (RGZ), against the perinatal nicotine-induced effect on offspring lung is also sex specific. Pregnant rat dams received placebo, nicotine, or nicotine plus RGZ daily from Embryonic Day 6 until Postnatal Day 21, at which time lung resistance, compliance, tracheal contractility, and the expression of structural and functional mesenchymal markers of pulmonary contractility were determined. Compared with control animals, perinatal nicotine exposure caused a significant increase in airway resistance and a decrease in airway compliance after a methacholine challenge in both male and female offspring, with more pronounced changes in the males. In contrast to this, the effects of perinatal nicotine exposure on acetylcholine-induced tracheal constriction, along with the expression of its mesenchymal markers, were observed exclusively in the male offspring. Concomitant treatment with RGZ normalized the nicotine-induced alterations in pulmonary function in both sexes, as well as the male-specific effects on acetylcholine-induced tracheal constriction, along with the affected mesenchymal markers. These data suggest that perinatal nicotine exposure causes sex-specific perinatal cigarette smoke exposure-induced asthma, providing a powerful phenotypic model for unequivocally determining the underlying nature of the cell molecular mechanism for this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.