ArticleProteomics. Clinical applications2012
Autoimmunoreactive IgGs from patients with postural orthostatic tachycardia syndrome.
Article in Proteomics. Clinical applications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Autoimmune Antibodies in Orthostatic Intolerance Syndromes.Physiological research · 2025Article
- Plasma proteomic profiling in postural orthostatic tachycardia syndrome (POTS) reveals new disease pathways.Scientific reports · 2022Article
- Preparing for the long-haul: Autonomic complications of COVID-19.Autonomic neuroscience : basic & clinical · 2021Review
- A functional cell-based bioassay for assessing adrenergic autoantibody activity in postural tachycardia syndrome.Journal of translational autoimmunity · 2019Article
- Review
- Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction.Cellular & molecular immunology · 2018Review
- Angiotensin II Type 1 Receptor Autoantibodies in Postural Tachycardia Syndrome.Journal of the American Heart Association · 2018Article
- Autoimmune postural orthostatic tachycardia syndrome.Annals of clinical and translational neurology · 2018Article
- Postural tachycardia syndrome: current perspectives.Vascular health and risk management · 2018Review
- Pediatric Disorders of Orthostatic Intolerance.Pediatrics · 2018Review
- Serum Resistin Negatively Correlates with Clinical Severity of Postural Tachycardia Syndrome in Children.Pediatric cardiology · 2017Article
- Autoimmunoreactive IgGs against cardiac lipid raft-associated proteins in patients with postural orthostatic tachycardia syndrome.Translational research : the journal of laboratory and clinical medicine · 2013Article
- Postural orthostatic tachycardia syndrome: when dysautonomia misleads: a mechanistic argument for compensatory orthostatic tachycardia.Frontiers in neurologyReview
- Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the "Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants": Case Report and Literature Review.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeAutoantibodies are implicated in the pathogenesis of cardiovascular diseases and cardiac arrhythmias. In this pilot study, we tested the hypothesis that autoantibodies are present in patients with postural orthostatic tachycardia syndrome (POTS). EXPERIMENTAL
designSeven control subjects (6 F:1 M, average age 36.1 years) and ten patients with the diagnosis of POTS (7 F: 3 M, average age 35.1 years) provided informed consent and 30 mL of venous blood. Human heart membrane proteins were resolved by 2DE and immunoblotted against purified IgGs from controls and patients.
resultsEighteen protein spots immunoreactive specifically against patient IgGs were detected and they were excised from gels, trypsin-digested, and analyzed by nanoLC-electrospray MS/MS. Forty unique proteins were identified and these include proteins that are associated with cardiac hypertrophy (mimecan, myozenin), cardiac remodeling (periostin), cardiomyopathy (desmin, desmoplakin), cell survival (laminin), structural integrity (filamin), chaperone proteins (crystalline, HSP70), mitochondrial enzymes, and channel proteins. Ingenuity Pathway Analysis showed multiple pathways were involved including those that regulate energy metabolism, redox, fibrosis, cardiac hypertrophy, and degeneration. CONCLUSIONS AND CLINICAL RELEVANCE: Autoantibodies are present in patients with POTS. These autoantibodies cross-react with a wide range of cardiac proteins and may induce alterations in cardiac function. Autoimmune pathogenetic mechanisms should be further explored in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.