ArticleJournal of clinical laboratory analysis2012
Relation of leptin and adiponectin with cardiovascular risk factors, intact parathormone, and vitamin D levels in patients with primary hyperparathyroidism.
Article in Journal of clinical laboratory analysis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Vitamin D and serum leptin: a systematic review and meta-analysis of observational studies and randomized controlled trials.European journal of clinical nutrition · 2017Pooled it
- Association between Serum Adiponectin and Vitamin D in Obese Pre- and Early Postmenopausal Women: A Cross-Sectional Study.Journal of menopausal medicine · 2026Article
- Leptin regulates parathyroid hormone secretion through CaSR-ERK1/2 signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- The intriguing connections of leptin to hyperparathyroidism.Endocrine · 2017Review
- The parathyroid leptin axis.Endocrine · 2017Article
- Visceral adiposity is a predictor of parathyroid hormone levels in healthy adults.Journal of endocrinological investigation · 2016Article
- High prevalence of metabolic syndrome in a mestizo group of adult patients with primary hyperparathyroidism (PHPT).BMC endocrine disorders · 2015Article
- Liver function parameters in hip fracture patients: relations to age, adipokines, comorbidities and outcomes.International journal of medical sciences · 2015Article
- Cardiovascular risk and metabolic syndrome in primary hyperparathyroidism and their correlation to different clinical forms.Endocrine · 2014Article
- Obesity, adipose tissue function and the role of vitamin D.Central-European journal of immunology · 2014Article
- Association between Vitamin D and Adiponectin and Its Relationship with Body Mass Index: The META-Health Study.Frontiers in public health · 2014Article
- Overexpression of adiponectin improves neurobehavioral outcomes after focal cerebral ischemia in aged mice.CNS neuroscience & therapeutics · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary hyperparathyroidism (PHPT) is associated with high cardiovascular morbidity. The aim of the present study was to explore the relationship of leptin and adiponectin levels with cardiovascular risk factors and anthropometric parameters in patients with PHTP with and without metabolic syndrome (MS).
methodsA total of 62 patients with PHPT were enrolled. Weight, blood pressure, basal glucose, insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, insulin, HOMA-R, intact parathormone, vitamin D, calcium, leptin, and adiponectin levels were measured in fasting condition.
resultsPrevalence of MS with ATP III definition was 32.3% (20 patients; 15 females (75%) and 5 males (25%)) and 67.7% patients without MS (n = 42 patients; 35 females (83.3%) and 7 males (16.7%)). In the analysis with leptin as dependent variable, the weight and HOMA-R levels remained in the model (F = 9.2; P < 0.05), with an increase of 1.31 (CI 95%: 0.24-2.31) ng/ml with each one unit of HOMA-R and an increase of 0.4 (CI 95%: 0.01-0.84) ng/ml with each 1 kg of weight. In a second model with adiponectin as dependent variable, the HOMA-R and HDL-cholesterol levels remained in the model (F = 7.37; P < 0.05), with a decrease of -0.62 (CI 95%: 0.01-1.1) ng/ml with each one point of HOMA-R and an increase of 0.18 (CI 95%: 0.04-0.38) ng/ml with each 1 mg/dl of HDL-cholesterol. In the multivariate, PTH I was not associated with other variables.
conclusionThere was a high prevalence of MS-32.3% of patients with PHPT presented an MS. Serum levels of leptin and adiponectin are not related with PTH I, vitamin D, and calcium levels in patients with PHPT.
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