Evidence map›Paper›PMID 23001637›Full record

ArticleLasers in surgery and medicine2012

Low-level laser therapy (808 nm) reduces inflammatory response and oxidative stress in rat tibialis anterior muscle after cryolesion.

Lívia Assis, Ana I S Moretti, Thalita B Abrahão, Vivian Cury, Heraldo P Souza, Michael R Hamblin, Nivaldo A Parizotto

Registry-linked trialOpen access · greenAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in surgery and medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05907915 (Donor Site Healing Response to Low Level Laser Therapy Following Skin Graft Surgery), which is not on this map. Cited by 55 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 3 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05907915 nacompletednot on this mapstarted 2022, after this paper: background citation

Donor Site Healing Response to Low Level Laser Therapy Following Skin Graft Surgery

TypeinterventionalSponsorCairo UniversityRan2022 to 2023Enrolled40ConditionsSkin GraftArmslow level laser therapy, placebo
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 125 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Lívia AssisLaboratory of Electrothermophototherapy, Department of Phisiotherapy, University of São Carlos, São Carlos, SP, Brazil.
Ana I S Moretti
Thalita B Abrahão
Vivian Cury
Heraldo P Souza
Michael R Hamblin
Nivaldo A Parizotto
Universidade Federal de São Carlos · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRInstituto de Assistência Médica ao Servidor Público EstadualMassachusetts General Hospital · US

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
NIAID NIH HHS R01 AI050875NIAID NIH HHS R01AI050875
6 · The paper itself

Abstract

BACKGROUND AND

objectiveMuscle regeneration is a complex phenomenon, involving coordinated activation of several cellular responses. During this process, oxidative stress and consequent tissue damage occur with a severity that may depend on the intensity and duration of the inflammatory response. Among the therapeutic approaches to attenuate inflammation and increase tissue repair, low-level laser therapy (LLLT) may be a safe and effective clinical procedure. The aim of this study was to evaluate the effects of LLLT on oxidative/nitrative stress and inflammatory mediators produced during a cryolesion of the tibialis anterior (TA) muscle in rats. MATERIAL AND

methodsSixty Wistar rats were randomly divided into three groups (n = 20): control (BC), injured TA muscle without LLLT (IC), injured TA muscle submitted to LLLT (IRI). The injured region was irradiated daily for 4 consecutive days, starting immediately after the lesion using a AlGaAs laser (continuous wave, 808 nm, tip area of 0.00785 cm(2) , power 30 mW, application time 47 seconds, fluence 180 J/cm(2) ; 3.8 mW/cm(2) ; and total energy 1.4 J). The animals were sacrificed on the fourth day after injury.

resultsLLLT reduced oxidative and nitrative stress in injured muscle, decreased lipid peroxidation, nitrotyrosine formation and NO production, probably due to reduction in iNOS protein expression. Moreover, LLLT increased SOD gene expression, and decreased the inflammatory response as measured by gene expression of NF-kβ and COX-2 and by TNF-α and IL-1β concentration.

conclusionThese results suggest that LLLT could be an effective therapeutic approach to modulate oxidative and nitrative stress and to reduce inflammation in injured muscle.

Indexed as

AnimalsBiomarkersCold TemperatureImmunoblottingInflammation MediatorsLasers, SemiconductorMaleMuscle, SkeletalOxidative StressRandom AllocationRatsRats, WistarReal-Time Polymerase Chain ReactionSoft Tissue InjuriesTreatment OutcomeWound HealingBiomarkersInflammation Mediators

Identifiers

PMID23001637
PMCPMC3516365
OpenAlexW2081630610

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.