ArticleEndocrine2013
Levothyroxine replacement therapy with vitamin E supplementation prevents oxidative stress and cognitive deficit in experimental hypothyroidism.
Article in Endocrine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pooled it
- Reactive oxygen species and intrinsic apoptotic markers in thyroid dysfunction: Insights from experimental animal models.Open veterinary journal · 2026Article
- Neuroinflammation and amyloid load in different age groups of individuals with Down syndrome: A PET imaging study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Thyroid Stimulatory Activity ofNutrients · 2025Article
- The Impact of Levothyroxine and Testosterone Administration on Bladder Contractility in the Rat Model of Propylthiouracil-Induced Hypothyroidism.Urology research & practice · 2025Article
- Vitamin E reduces oxidative stress in brains of male albino male rats undergoing immobilization.Saudi journal of biological sciences · 2024Article
- Vitamin E Prevented Hepatic and Renal Tissue Damage in Hypothyroid Rats.Advanced biomedical research · 2023Article
- The effects of vitamin D on learning and memory of hypothyroid juvenile rats and brain tissue acetylcholinesterase activity and oxidative stress indicators.Naunyn-Schmiedeberg's archives of pharmacology · 2022Article
- α-Lipoic Acid Ameliorates The Changes in Prooxidant-Antioxidant Balance in Liver and Brain Tissues of Propylthiouracil-Induced Hypothyroid Rats.Cell journal · 2020Article
- Role of levothyroxine and vitamin E supplementation in the treatment of oxidative stress-induced injury and apoptosis of myocardial cells in hypothyroid rats.Journal of endocrinological investigation · 2017Article
- The effects of vitamin C on hypothyroidism-associated learning and memory impairment in juvenile rats.Metabolic brain disease · 2017Article
- Contribution of Brain Tissue Oxidative Damage in Hypothyroidism-associated Learning and Memory Impairments.Advanced biomedical research · 2017Review
- Effects ofFood science and biotechnology · 2016Article
- Protective Effect of PPARNeurology research international · 2016Article
- Thyroid Hormones, Oxidative Stress, and Inflammation.Mediators of inflammation · 2016Review
- Co-administration of Apelin and T4 protects inotropic and chronotropic changes occurring in hypothyroid rats.Arquivos brasileiros de cardiologia · 2015Article
- Oxidative stress in patients with thyroidectomy and thyroparathyroidectomy under replacement therapy.Endocrine · 2015Article
- Vitamin E management of oxidative damage-linked dysfunctions of hyperthyroid tissues.Cellular and molecular life sciences : CMLS · 2013Review
- The role of thyroid hormones as inductors of oxidative stress and neurodegeneration.Oxidative medicine and cellular longevity · 2013Review
- Insulin Plant (Pharmacognosy researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypothyroidism has a variety of adverse effects on cognitive function. The treatment of levothyroxine alone cannot restore cognitive defects of hypothyroid patients. Antioxidant vitamin E supplementation could be useful in disturbances which are associated with oxidative stress and could effectively slow the progression of Alzheimer disease. Thus, the purpose of this study was to evaluate oxidative stress status of the serum and hippocampus in hypothyroidism and to examine the effects of levothyroxine replacement therapy with vitamin E supplementation on cognitive deficit. Sprague-Dawley rats were randomly divided into five groups: control group, PTU group, PTU + Vit E group, PTU + L-T4 group, and PTU + L-T4 + Vit E group. Serum and hippocampus malondialdehyde (MDA) levels were determined using the thiobarbituric-acid reactive substances method. Serum and hippocampus superoxide dismutase (SOD) levels were determined by measuring its ability to inhibit the photoreduction of nitroblue tetrazolium. Learning and memory was assessed by Morris water maze test. In the present study, we found that the rats of PTU + Vit E group spent less time to find the platform on days 2, 3, 4, and 5 than the PTU group. Moreover, the rats of PTU + L-T4 + Vit E group spent less time to find the platform on days 4 and 5 than the PTU + L-T4 group. The time spent in the target quadrants was measured in the probe test and no difference was observed in all groups. Oxidative damage has been observed in the serum and hippocampus of hypothyroidism rat. SOD levels of serum and hippocampus tissue were significantly increased and MDA levels were significantly decreased in the PTU + Vit E and PTU + L-T4 + Vit E groups than the PTU and PTU + L-T4 groups. Therefore, these findings indicate that levothyroxine replacement therapy with vitamin E supplementation may ameliorate cognitive deficit in PTU-induced hypothyroidism through the decrease of oxidative stress status.
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