ArticleJournal of genetic counseling2013
Variables influencing pregnancy termination following prenatal diagnosis of fetal chromosome abnormalities.
Article in Journal of genetic counseling, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Parental decision-making following a prenatal diagnosis that is lethal, life-limiting, or has long term implications for the future child and family: a meta-synthesis of qualitative literature.BMC medical ethics · 2019Pooled it
- Evaluating pregnancy termination rates for fetal chromosome and single gene disorders.Journal of genetic counseling · 2025Article
- Factors affecting parental decisions for termination of pregnancy in the presence of a prenatal trisomy 21 diagnosis.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Parental information about the option to apply for pregnancy termination after the detection of a congenital abnormality and factors influencing parental decision-making: a cohort study.BMC pregnancy and childbirth · 2022Article
- Sociodemographic Differences in Prenatal Diagnosis of Chromosomal Anomalies: A Population-Based Study.Frontiers in pediatrics · 2021Article
- Epistemic Virtue, Prospective Parents and Disability Abortion.Journal of bioethical inquiry · 2019Article
- Investigating Pregnancy Outcomes After Abnormal Cell-Free DNA Test Results.Journal of genetic counseling · 2018Article
- Parent Perspectives of Support Received from Physicians and/or Genetic Counselors Following a Decision to Continue a Pregnancy with a Prenatal Diagnosis of Trisomy 13/18.Journal of genetic counseling · 2018Article
- Older mothers and increased impact of prenatal screening: stable livebirth prevalence of trisomy 21 in the Netherlands for the period 2000-2013.European journal of human genetics : EJHG · 2018Article
- A Qualitative Study of Factors Influencing Decision-Making after Prenatal Diagnosis of down Syndrome.Journal of genetic counseling · 2017Article
- Pregnancy Outcome following Prenatal Diagnosis of Chromosomal Anomaly: A Record Linkage Study of 26,261 Pregnancies.PloS one · 2016Article
- We want what's best for our baby: Prenatal Parenting of Babies with Lethal Conditions.Journal of prenatal & perinatal psychology & health · 2015Article
- Parental decisions following prenatal diagnosis of chromosomal abnormalities: implications for genetic counseling practice in Japan.Journal of genetic counseling · 2015Article
- NIPT in a clinical setting: an analysis of uptake in the first months of clinical availability.Journal of genetic counseling · 2014Article
- The decision to continue a pregnancy affected by Down syndrome: timing of decision and satisfaction with receiving a prenatal diagnosis.Journal of genetic counseling · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to identify variables that may influence the decision to terminate or continue a pregnancy affected by a chromosome abnormality. We performed a retrospective cohort analysis of 286 pregnancies diagnosed with a chromosome abnormality following genetic counseling and prenatal diagnosis. Data obtained included procedure type, chromosome results, ethnicity, maternal age, use of fertility treatments, and uptake of genetic counseling after results, among other factors. Wilcoxon rank sum test, Fisher's exact test, and univariate and multivariate logistic regression models were used for data analysis. The overall termination rate in this study was 82.9 %. A lower likelihood to terminate was found in pregnancies with a diagnosis of a sex chromosome abnormality (OR 0.05, p < .0001), Filipina race (OR 0.10, p = .03), and uptake of second genetic counseling session (OR 0.05, p < .0001). Prior history of termination was associated with increased likelihood to terminate (OR 8.6, p = .02). Factors revealing no statistically significant association with termination included maternal age, gestational age, clinic site, fetal gender, ultrasound anomalies, reason for referral and who informed the patient. Our data affirm the complexity of the decision making process and reinforce that providers should refrain from making assumptions regarding a patient's likelihood to terminate based on factors such as maternal age, gestational age, type of procedure, or ultrasound.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.