ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2013
Up-regulated tumor necrosis factor-associated factor 6 level is correlated with apoptosis in the rat cerebral ischemia and reperfusion.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 35 citations in OpenAlex.
- MiR-146a-5p downregulated TRAF6/NF-κB p65 pathway to attenuate the injury of HT-22 cells induced by oxygen-glucose deprivation/reoxygenation.In vitro cellular & developmental biology. Animal · 2025Article
- The significance of calcium ions in cerebral ischemia-reperfusion injury: mechanisms and intervention strategies.Frontiers in molecular biosciences · 2025Review
- The circular RNA circ_0099630/miR-940/receptor-associated factor 6 regulation cascade modulates the pathogenesis of periodontitis.Journal of dental sciences · 2022Article
- Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies.Neural regeneration research · 2022Article
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- Roles of TRAF6 in Central Nervous System.Current neuropharmacology · 2018Review
- The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Socs1 and Socs3 degrades Traf6 via polyubiquitination in LPS-induced acute necrotizing pancreatitis.Cell death & disease · 2015Article
- Association Between TRAF6 Gene Polymorphisms and Susceptibility of Ischemic Stroke in Southern Chinese Han Population.Journal of molecular neuroscience : MN · 2015Article
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- miR-146a ameliorates liver ischemia/reperfusion injury by suppressing IRAK1 and TRAF6.PloS one · 2014Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor necrosis-associated factor 6 (TRAF6) performs critical roles in mediating apoptosis-associated inflammatory processes in multiple cell types, but its role in cerebral ischemia-reperfusion (I/R) injury is still unclear. In the present study, we established a middle cerebral artery occlusion (MCAO) reperfusion model in rat, and evaluated both the cerebral inflammatory damage and the cell apoptosis by TTC staining and TUNEL method, respectively. The expression of TRAF6 and the neural cell apoptosis was examined during the I/R pathophysiological process. Cerebral ischemia injury induced significant neuronal cell apoptosis, but after the onset of reperfusion, cell apoptosis was gradually alleviated. In accord with the trend of I/R injury and cell apoptosis, up-regulated TRAF6 mRNA expression and caspase-3 cleavage level were observed in the ischemia stage and the early stage of reperfusion accordingly, which indicated that the activation of TRAF6 correlated positively with the cell apoptosis. Immunohistochemistry staining further showed that the TRAF6 was mainly localized in the neuronal cells. Thus, our study suggested that TRAF6 is involved in the inflammatory process induced by cerebral ischemia-reperfusion, and functions partially as a pro-inflammatory adaptor to mediate cell apoptosis.
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