ArticleCurrent microbiology2012
A combined use of autolysin p60 and listeriolysin O antigens induces high protective immune responses against Listeria monocytogenes infection.
Article in Current microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Development and application of ActA-based competitive ELISA for the specific diagnosis of ovine listeriosis.BMC veterinary research · 2025Article
- Maximizing Immunopeptidomics-Based Bacterial Epitope Discovery by Multiple Search Engines and Rescoring.Journal of proteome research · 2025Article
- The inactivated and ISA 61 VG adjuvanted vaccine enhances protection against cross-serotype Listeria monocytogenes.Veterinary research · 2025Article
- Complete genome of the Listeria monocytogenes strain AUF, used as a live listeriosis veterinary vaccine.Scientific data · 2024Article
- Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes.Nature communications · 2022Article
- Article
- A Cross-Protective Vaccine Against 4b and 1/2bFrontiers in microbiology · 2020Article
- Characterization of the pathogenesis and immune response to Listeria monocytogenes strains isolated from a sustained national outbreak.Scientific reports · 2019Article
- Biological effects of listeriolysin O: implications for vaccination.BioMed research international · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Listeria monocytogenes is an intracellular bacterium responsible for listeriosis in both humans and animals. Infected livestock is believed to be one source of this pathogen. Vaccination is an optimal approach to control the occurrence of this disease in livestock. However, inactivated vaccines have been reported to be insufficient to offer immune protection against L. monocytogenes. Here we evaluated the immune protection capacity of a combination of recombinant p60 and LLO. Mice immunized with p60 and LLO generated a high level of anti-L. monocytogenes antibodies. In addition, the elevated levels of IFN-γ and the decreased levels of IL-4 were also observed in these treated mice. Consistent with the colonization of L. monocytogenes post infection, all mice in the control group died within 5 days after infection of L. monocytogenes, while 40, 40, 80, and 100 % of animals immunized with inactivated L. monocytogenes vaccine (ILMV), LLO + ILMV, p60 + ILMV, and p60 + LLO + ILMV, respectively, survived for 2 weeks. Collectively, the results presented in this study demonstrate the capacity of a combination of LLO and p60 to elicit high protective immune responses against L. monocytogenes infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.