Evidence map›Paper›PMID 23001383›Full record

ArticleProceedings of the ... American Control Conference. American Control Conference2011

Approximate-model closed-loop minimal sampling method for HIV viral-load minima detection.

Ryan Zurakowski, Matthew Churgin, Camilo Perez, Matthew Rodriguez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the ... American Control Conference. American Control Conference, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Measurement error robustness of a closed-loop minimal sampling method for HIV therapy switching.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryan ZurakowskiElectrical and Computer Engineering, University of Delaware, Newark, DE 19716, USA, ryanz@udel.edu.
Matthew Churgin
Camilo Perez
Matthew Rodriguez

Funding

Analysis of Differential Resistance Emergence Risk for Differential Treatment AppR21AI078842 · NIAID · UNIVERSITY OF DELAWARE · PI ZURAKOWSKI, RYAN M · 2009 to 2010
$396k
NIAID NIH HHS R21 AI078842
6 · The paper itself

Abstract

We present a closed-loop method for determining the minimum of a viral rebound curve for an HIV patient undergoing a therapy transition. This method fits the parameters for a reduced approximate solution to the viral load measurements using a Simulated Annealing direct search algorithm. Gaussian white noise is added, and a family of fits is obtained. A safety tolerance measure is applied to the family of fits to obtain the next sample time. Using parameters identified from HIV data, we show that this method exhibits robust performance on noisy data generated from identified patient models, while greatly reducing the number of samples needed compared to a fixed-interval sampling approach.

Identifiers

PMID23001383
PMCPMC3445656

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.