ArticleDiabetologia2012
Islet nerves in focus--defining their neurobiological and clinical role.
Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Human liver and pancreas innervation: resolving 3D neurohistological challenges and advancing insights.Journal of biomedical science · 2025Review
- The stem cell within the vessel wall: multipotent pericytes modulating β-cell function and diabetic complications.Stem cell research & therapy · 2025Review
- Electroacupuncture at ST25 mediated glial cells pruning of pancreatic TRPV1 neural synapse responds to neuropathy-associated beta cell dysfunction.Chinese medicine · 2025Article
- Network representation of multicellular activity in pancreatic islets: Technical considerations for functional connectivity analysis.PLoS computational biology · 2024Article
- Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.Scientific reports · 2021Article
- Organisation of the human pancreas in health and in diabetes.Diabetologia · 2020Review
- The beneficial effects of a muscarinic agonist on pancreatic β-cells.Scientific reports · 2019Article
- The Role of Accessory Cells in Islet Homeostasis.Current diabetes reports · 2018Review
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- PanIN-associated pericyte, glial, and islet remodeling in mice revealed by 3D pancreatic duct lesion histology.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- 3-D imaging of islets in obesity: formation of the islet-duct complex and neurovascular remodeling in young hyperphagic mice.International journal of obesity (2005) · 2016Article
- Hormonal Responses to Cholinergic Input Are Different in Humans with and without Type 2 Diabetes Mellitus.PloS one · 2016Article
- Vagotomy ameliorates islet morphofunction and body metabolic homeostasis in MSG-obese rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- 3-D Imaging Reveals Participation of Donor Islet Schwann Cells and Pericytes in Islet Transplantation and Graft Neurovascular Regeneration.EBioMedicine · 2015Article
- Episodic hormone secretion: a comparison of the basis of pulsatile secretion of insulin and GnRH.Endocrine · 2014Review
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1 author.
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Abstract
Although it is well established that the pancreatic islets are innervated by autonomic nerves, the detailed islet innervation pattern is still unclear. In this issue of Diabetologia (DOI: 10.1007/s00125-012-2699-6 ) novel details of the islet neuroanatomy and its plasticity in experimental diabetes are described. By using a 3-dimensional (3-D) imaging technique, it has been shown that, in islets from normal mice, sympathetic nerves mainly form a neurovascular complex in addition to innervating peripherally located islet alpha cells. There are also pronounced changes in islet neuroanatomy in experimental diabetes. These findings suggest novel neural-islet regulatory mechanisms as well as neural involvement in the development of diabetes, and therefore advance both basic and clinical knowledge of islet neurobiology.
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