ArticleJournal of occupational and environmental medicine2012
Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma.
Article in Journal of occupational and environmental medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02027415 (Effects of Oral Nitrate Supplementation on Vascular and Pulmonary Oxidative Stress Markers Following Traffic Pollution Exposure), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Oral Nitrate Supplementation on Vascular and Pulmonary Oxidative Stress Markers Following Traffic Pollution Exposure
Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- A controlled trial of acute effects of human exposure to traffic particles on pulmonary oxidative stress and heart rate variability.Particle and fibre toxicology · 2014Trial
- MicroRNA expression in response to controlled exposure to diesel exhaust: attenuation by the antioxidant N-acetylcysteine in a randomized crossover study.Environmental health perspectives · 2013Trial
- Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke.Particle and fibre toxicology · 2024Review
- Traffic-related air pollution, chronic stress, and changes in exhaled nitric oxide and lung function among a panel of children with asthma living in an underresourced community.The Science of the total environment · 2024Article
- Controlled human exposure to diesel exhaust: a method for understanding health effects of traffic-related air pollution.Particle and fibre toxicology · 2022Review
- The pro-inflammatory effects of combined exposure to diesel exhaust particles and mineral particles in human bronchial epithelial cells.Particle and fibre toxicology · 2022Article
- Controlled human exposure to diesel exhaust: results illuminate health effects of traffic-related air pollution and inform future directions.Particle and fibre toxicology · 2022Review
- The Correlation of PM2.5 Exposure with Acute Attack and Steroid Sensitivity in Asthma.BioMed research international · 2022Review
- Exposure to traffic-related air pollution and changes in exhaled nitric oxide and DNA methylation in arginase and nitric oxide synthase in children with asthma.Environmental health : a global access science source · 2021Article
- Role of tumor necrosis factor-α and its receptors in diesel exhaust particle-induced pulmonary inflammation.Scientific reports · 2017Article
- Toward point-of-care management of chronic respiratory conditions: Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide.Microsystems & nanoengineering · 2017Article
- TRP channels and traffic-related environmental pollution-induced pulmonary disease.Seminars in immunopathology · 2016Review
- Does aspirin-induced oxidative stress cause asthma exacerbation?Archives of medical science : AMS · 2015Article
- What can individuals do to reduce personal health risks from air pollution?Journal of thoracic disease · 2015Review
- Assessment of Particulate Matter Levels in Vulnerable Communities in North Charleston, South Carolina prior to Port Expansion.Environmental health insights · 2014Article
- Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications.Journal of exposure science & environmental epidemiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo determine whether oxidative/nitrosative stress plays a role in the acute effects of diesel exhaust (DE) on subjects with asthma.
methodsIn this crossover study, 16 subjects with mild to moderate asthma were exposed to clean filtered air or diluted DE (300 μg/m as PM2.5) for 1 hour with intermittent exercise.
resultsAirway hyperreactivity increased 24 hours after exposure to DE compared with clean filtered air (PC20, 14.9 mg/mL vs 19.7 mg/mL; P = 0.012). Nitrite in exhaled breath condensate was elevated immediately after diesel exposure (P = 0.052) and remained elevated 4 and 24 hours after exposure.
conclusionsAfter exposure to DE, subjects with asthma demonstrated increased airway hyperreactivity and obstruction. Increased nitrite in exhaled breath condensate, in the absence of increased exhaled nitric oxide, suggests a noninflammatory oxidative stress mechanism by which DE affects the lung.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.