SynthesisThe journal of headache and pain2012
A systematic review of the psychosocial difficulties relevant to patients with migraine.
Synthesis in The journal of headache and pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 4 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- The efficacy and safety of atogepant for the prophylactic treatment of migraine: evidence from randomized controlled trials.The journal of headache and pain · 2022Pooled it
- Pooled it
- The lived experience of chronic headache: a systematic review and synthesis of the qualitative literature.BMJ open · 2017Pooled it
- Narratives reflecting the lived experiences of people with brain disorders: common psychosocial difficulties and determinants.PloS one · 2014Pooled it
- Shift from high-frequency to low-frequency episodic migraine in patients treated with Galcanezumab: results from two global randomized clinical trials.The journal of headache and pain · 2021Trial
- Functional impairment and disability among patients with migraine: evaluation of galcanezumab in a long-term, open-label study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Trial
- Changes in patient functioning and disability: results from a phase 3, double-blind, randomized, placebo-controlled clinical trial evaluating galcanezumab for chronic migraine prevention (REGAIN).Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Trial
- Trial
- Two randomized migraine studies of galcanezumab: Effects on patient functioning and disability.Neurology · 2019Trial
- Migraine and Work-Disability: New Treatments Reduce Work-Related Burden Among Migraine Population.European journal of neurology · 2026Article
- Beyond headache: non-cephalic pain, fatigue, and post-traumatic stress symptoms as longitudinal predictors of chronic migraine outcomes.Pain medicine (Malden, Mass.) · 2026Article
- Impact of migraine on quality of life and disability: a matched cross-sectional comparative study in a tertiary hospital in Malaysia.Frontiers in neurology · 2026Article
- Real-World Safety and Efficacy of 156 U - 195 U OnabotulinumtoxinA in Adults With Chronic Migraine: Results From the REPOSE Study.BMC neurology · 2025Observational
- Association between mental disorders and trigeminal neuralgia: a cohort study and Mendelian randomization analysis.The journal of headache and pain · 2025Article
- Anxiety Disorders, Anxious Symptomology and Related Behaviors Associated With Migraine: A Narrative Review of Prevalence and Impact.Current pain and headache reports · 2025Review
- Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024Review
- Characteristics of locus coeruleus functional connectivity network in patients with comorbid migraine and insomnia.The journal of headache and pain · 2024Article
- Headache and Associated Psychological Variables in Intensive Care Unit Nurses during the COVID-19 Pandemic: A Prospective Study.Journal of clinical medicine · 2024Article
- Healthcare utilisation and economic burden of migraines among bank employees in China: a probabilistic modelling study.The journal of headache and pain · 2024Article
- Theory of mind in chronic migraine with medication overuse assessed with the MASC.Scientific reports · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a common disease which causes significant burden to individuals, in terms of personal suffering and activity reduction, and to societies, in terms of disease cost. The purpose of this study is to identify the most relevant psychosocial difficulties related to migraine, the variables associated with them and the most relevant determinants of their evolution over time. MEDLINE and PsychINFO were searched for studies published in English between 2000 and 2010 that examined psychosocial difficulties in persons with migraine with and without aura, from clinical trials and observational studies. Information on the description of each difficulty, its determinants of onset and change over time and associated variables were extracted and categorized at a higher level. In total, 34 difficulties have been collected from 51 papers: the most frequent were reduced vitality and fatigue, emotional problems, pain, difficulties at work, general physical and mental health, social functioning and global disability. Evidence exists that pharmacological treatments have an impact toward improvement in patients' difficulties, in particular emotional problems, physical and mental health, difficulties with employment and global disability. Migraine treatments and decreased headaches frequency are the major determinants of improvements in psychosocial difficulties, while no information is available for determinants of worsening; understanding the role of such factors is of primary public health relevance, given the high prevalence and the relevant personal and societal costs of migraine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.