ReviewExercise and sport sciences reviews2012
Effect of statins on skeletal muscle: exercise, myopathy, and muscle outcomes.
Review in Exercise and sport sciences reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 54 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being
Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being
LIFESTAT - Living With Statins, a Cross Sectional Study on the Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being
Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- Muscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: past, present, and future.Pharmacological reports : PR · 2020Pooled it
- Myopathy in older people receiving statin therapy: a systematic review and meta-analysis.British journal of clinical pharmacology · 2015Pooled it
- GATM polymorphism associated with the risk for statin-induced myopathy does not replicate in case-control analysis of 715 dyslipidemic individuals.Cell metabolism · 2015Pooled it
- The effect of statins on the survival of patients with amyotrophic lateral sclerosis: a meta-analysis.Frontiers in neurologyPooled it
- Trial
- The relationship of fasting hyperglycemia to changes in fat and muscle mass after exercise training in type 2 diabetes.Diabetes research and clinical practice · 2016Trial
- The Effect of Atorvastatin on Habitual Physical Activity among Healthy Adults.Medicine and science in sports and exercise · 2016Trial
- Rhabdomyolysis presenting as abdominal pain: importance of early creatine kinase testing.Annals of medicine and surgery (2012) · 2026Article
- Risk of Sarcopenia Following Long-Term Statin Use in Community-Dwelling Middle-Aged and Older Adults in Japan.Journal of cachexia, sarcopenia and muscle · 2025Article
- Effect of Common Medications on Longitudinal Pectoralis Muscle Area in Smokers.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Characteristics, Physiopathology and Management of Dyslipidemias in Pregnancy: A Narrative Review.Nutrients · 2024Review
- Drug-related sarcopenia as a secondary sarcopenia.Geriatrics & gerontology international · 2024Review
- Eupatilin Alleviates Hyperlipidemia in Mice by Inhibiting HMG-CoA Reductase.Biochemistry research international · 2023Article
- Article
- Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older Individuals.Frontiers in physiology · 2022Article
- Simvastatin-Loaded Nanofibrous Membrane Efficiency on the Repair of Achilles Tendons.International journal of nanomedicine · 2022Article
- Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy.International journal of molecular sciences · 2021Review
- Dietary Habits and Musculoskeletal Pain in Statin and Red Yeast Rice Users: A Pilot Study.European journal of investigation in health, psychology and education · 2021Article
- Simvastatin does not alleviate muscle pathology in a mouse model of Duchenne muscular dystrophy.Skeletal muscle · 2021Article
- Assessing the Interactions of Statins with Human Adenylate Kinase Isoenzyme 1: Fluorescence and Enzyme Kinetic Studies.International journal of molecular sciences · 2021Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Statins are effective in reducing low-density lipoprotein cholesterol and cardiac events but can produce muscle side effects. We have hypothesized that statin-related muscle complaints are exacerbated by exercise and influenced by factors including mitochondrial dysfunction, membrane disruption, and/or calcium handling. The interaction between statins, exercise, and muscle symptoms may be more effectively diagnosed and treated as rigorous scientific studies accumulate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.