ArticleNeuroscience2012
Cross-sensitization of histamine-independent itch in mouse primary sensory neurons.
Article in Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Dual function of MrgprB2 receptor-dependent neural immune axis in chronic pain.Journal of advanced research · 2025Article
- Article
- Evaluation of itch and pain induced by bovine adrenal medulla (BAM)8-22, a new human model of non-histaminergic itch.Experimental dermatology · 2022Article
- Generalized resistance to pruritogen-induced scratching in the C3H/HeJ strain.Frontiers in molecular neuroscience · 2022Article
- Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory Neurons.Marine drugs · 2021Article
- How Do Neurons Signal Itch?Frontiers in medicine · 2021Review
- Thermal Hyperalgesia and Mechanical Allodynia Elicited by Histamine and Non-histaminergic Itch Mediators: Respective Involvement of TRPV1 and TRPA1.Neuroscience · 2020Article
- The Challenge of Basic Itch Research.Acta dermato-venereologica · 2020Review
- Calcium imaging of primary canine sensory neurons: Small-diameter neurons responsive to pruritogens and algogens.Brain and behavior · 2019Article
- Itch Processing in the Skin.Frontiers in medicine · 2019Review
- Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations.Science signaling · 2016Article
- Nalfurafine suppresses pruritogen- and touch-evoked scratching behavior in models of acute and chronic itch in mice.Acta dermato-venereologica · 2015Article
- Article
- Protease-activated receptors and itch.Handbook of experimental pharmacology · 2015Review
- Role of spinal bombesin-responsive neurons in nonhistaminergic itch.Journal of neurophysiology · 2014Article
- Differential signaling by protease-activated receptors: implications for therapeutic targeting.International journal of molecular sciences · 2014Review
- Neural processing of itch.Neuroscience · 2013Review
- Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.Nature neuroscience · 2013Article
- Roles for substance P and gastrin-releasing peptide as neurotransmitters released by primary afferent pruriceptors.Journal of neurophysiology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Overexpression of pruritogens and their precursors may contribute to the sensitization of histamine-dependent and -independent itch-signaling pathways in chronic itch. We presently investigated self- and cross-sensitization of scratching behavior elicited by various pruritogens, and their effects on primary sensory neurons. The MrgprC11 agonist BAM8-22 exhibited self- and reciprocal cross-sensitization of scratching evoked by the protease-activated receptor-2 (PAR-2) agonist SLIGRL. The MrgprA3 agonist chloroquine unidirectionally cross-sensitized BAM8-22-evoked scratching. Histamine unidirectionally cross-sensitized scratching evoked by chloroquine and BAM8-22. SLIGRL unidirectionally cross-sensitized scratching evoked by chloroquine. Dorsal root ganglion (DRG) cells responded to various combinations of pruritogens and algogens. Neither chloroquine, BAM8-22 nor histamine had any effect on responses of DRG cell responses to subsequently applied pruritogens, implying that their behavioral self- and cross-sensitization effects are mediated indirectly. SLIGRL unilaterally cross-sensitized responses of DRG cells to chloroquine and BAM8-22, consistent with the behavioral data. These results indicate that unidirectional cross-sensitization of histamine-independent itch-signaling pathways might occur at a peripheral site through PAR-2. PAR-2 expressed in pruriceptive nerve endings is a potential target to reduce sensitization associated with chronic itch.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.