Evidence map›Paper›PMID 23000482›Full record

ReviewBiochimica et biophysica acta2013

RNA polymerase II transcription: structure and mechanism.

Xin Liu, David A Bushnell, Roger D Kornberg

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed.

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  12. Structural basis of transcription: RNA polymerase II substrate binding and metal coordination using a free-electron laser.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
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  15. Article
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  18. Review
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xin LiuDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
David A Bushnell
Roger D Kornberg

Funding

Structure of the Eukaryote Transcription ApparatusR01AI021144 · NIAID · STANFORD UNIVERSITY · PI KORNBERG, ROGER D · 1985 to 2018
$10.3M
STRUCTURE OF RNA POLYMERASE IIR01GM049985 · NIGMS · STANFORD UNIVERSITY · PI PUGLISI, JOSEPH D · 1993 to 2020
$10.2M
RNA POLYMERASE II TRANSCRIPTION SYSTEM FROM YEASTR01GM036659 · NIGMS · STANFORD UNIVERSITY · PI KORNBERG, ROGER D · 1986 to 2016
$4.7M
Facilitating large scale biomass generation: acquisition of an automated 100 L feS10RR028096 · NCRR · STANFORD UNIVERSITY · PI KORNBERG, ROGER D · 2010 to 2010
$324k
NCRR NIH HHS S10 RR028096NIAID NIH HHS R01 AI021144NIGMS NIH HHS R01 GM036659NIGMS NIH HHS R01 GM049985
6 · The paper itself

Abstract

A minimal RNA polymerase II (pol II) transcription system comprises the polymerase and five general transcription factors (GTFs) TFIIB, -D, -E, -F, and -H. The addition of Mediator enables a response to regulatory factors. The GTFs are required for promoter recognition and the initiation of transcription. Following initiation, pol II alone is capable of RNA transcript elongation and of proofreading. Structural studies reviewed here reveal roles of GTFs in the initiation process and shed light on the transcription elongation mechanism. This article is part of a Special Issue entitled: RNA Polymerase II Transcript Elongation.

Indexed as

Amino Acid SequenceAnimalsHumansModels, BiologicalModels, MolecularMolecular Sequence DataRNA Polymerase IISequence Homology, Amino AcidStructure-Activity RelationshipTranscription Factors, GeneralTranscription, GeneticRNA Polymerase IITranscription Factors, General

Identifiers

PMID23000482
PMCPMC4244541

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.