ArticleDevelopmental biology2012
Sprouty/FGF signaling regulates the proximal-distal feather morphology and the size of dermal papillae.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
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- Comparative Transcriptomics of Feather Follicles Reveals Potential Candidate Genes for Duck Feather Type Differentiation.Animals : an open access journal from MDPI · 2026Article
- Novel tissue mechanics-guided cellular flows drive the formation of feather follicles.The EMBO journal · 2026Article
- Sexually dimorphic sail feathers in the Mandarin duck as a model for lifelong developmental modulation.Scientific reports · 2025Article
- Regulation of feather length: FGF/IGF signaling and NOTCH/YAP modulation of progenitor cell topology.Science advances · 2025Article
- Cyclic renewal in three ectodermal appendage follicles: Hairs, feathers and teeth.Developmental biology · 2025Review
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
- A molecular mechanism for bright color variation in parrots.Science (New York, N.Y.) · 2024Article
- Transcriptome and Weighted Gene Co-Expression Network Analysis for Feather Follicle Density in a Chinese Indigenous Breed.Animals : an open access journal from MDPI · 2024Article
- The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendages.Biological reviews of the Cambridge Philosophical Society · 2021Article
- Cyclic growth of dermal papilla and regeneration of follicular mesenchymal components during feather cycling.Development (Cambridge, England) · 2021Article
- Making region-specific integumentary organs in birds: evolution and modifications.Current opinion in genetics & development · 2021Review
- Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells.Clinical, cosmetic and investigational dermatology · 2021Article
- The Wnt/β-catenin signaling pathway is involved in regulating feather growth of embryonic chicks.Poultry science · 2020Article
- Whole-genome resequencing reveals genetic indels of feathered-leg traits in domestic chickens.Journal of genetics · 2019Article
- Morpho-regulation in diverse chicken feather formation: Integrating branching modules and sex hormone-dependent morpho-regulatory modules.Development, growth & differentiation · 2019Article
- Transmission electron microscopic and immunohistochemical observations of resting follicles of feathers in chicken show massive cell degeneration.Anatomical science international · 2018Article
- Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling.Nature communications · 2018Article
- Establishment of an immortalized mouse dermal papilla cell strain with optimized culture strategy.PeerJ · 2018Article
- Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme.Nature communications · 2017Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
In a feather, there are distinct morphologies along the proximal-distal axis. The proximal part is a cylindrical stalk (calamus), whereas the distal part has barb and barbule branches. Here we focus on what molecular signaling activity can modulate feather stem cells to generate these distinct morphologies. We demonstrate the drastic tissue remodeling during feather cycling which includes initiation, growth and resting phases. In the growth phase, epithelial components undergo progressive changes from the collar growth zone to the ramogenic zone, to maturing barb branches along the proximal-distal axis. Mesenchymal components also undergo progressive changes from the dermal papilla, to the collar mesenchyme, to the pulp along the proximal-distal axis. Over-expression of Spry4, a negative regulator of receptor tyrosine kinases, promotes barb branch formation at the expense of the epidermal collar. It even induces barb branches from the follicle sheath (equivalent to the outer root sheath in hair follicles). The results are feathers with expanded feather vane regions and small or missing proximal feather shafts (the calamus). Spry4 also expands the pulp region while reducing the size of dermal papillae, leading to a failure to regenerate. In contrast, over-expressing Fgf10 increases the size of the dermal papillae, expands collar epithelia and mesenchyme, but also prevents feather branch formation and feather keratin differentiation. These results suggest that coordinated Sprouty/FGF pathway activity at different stages is important to modulate feather epidermal stem cells to form distinct feather morphologies along the proximal-distal feather axis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.