ReviewFrontiers in neuroendocrinology2012
Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise.
Review in Frontiers in neuroendocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 222 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
222 citing papers in PubMed, 5 syntheses or guidelines pooled it, 373 citations in OpenAlex.
- Sertraline as an Antidepressant and Inflammatory Cytokines in Depressive Disorders: A Systematic Review and Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Neuro-Behçet's Disease and Psychiatric Disorders: From a Case Report to a Systematic Review.Brain and behavior · 2026Pooled it
- Association of Kawasaki disease with intellectual disability, attention deficit hyperactivity disorder, and autism spectrum disorder: a systematic review and meta-analysis.Italian journal of pediatrics · 2025Pooled it
- Predictors of successful anti-inflammatory drug trials in patients with schizophrenia: A meta-regression and critical commentary.Brain, behavior, and immunity · 2023Pooled it
- Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review.Molecular psychiatry · 2016Pooled it
- Frailty and Depression in Late Life: A High-Risk Comorbidity With Distinctive Clinical Presentation and Poor Antidepressant Response.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Randomized Controlled Phase II Evaluation of Two Dose Levels of Bupropion Versus Placebo for Sexual Desire in Female Cancer Survivors: NRG-CC004.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Trial
- Biological motion during inflammation in humans.Brain, behavior, and immunity · 2020Trial
- Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue.Scientific reports · 2019Trial
- Dose-Dependent Effects of Oral Tyrosine Administration on Plasma Tyrosine Levels and Cognition in Aging.Nutrients · 2017Trial
- Lipopolysaccharide Alters Motivated Behavior in a Monetary Reward Task: a Randomized Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- A Neurocomputational Account of How Inflammation Enhances Sensitivity to Punishments Versus Rewards.Biological psychiatry · 2016Trial
- Effect of 2 psychotherapies on depression and disease activity in pediatric Crohn's disease.Inflammatory bowel diseases · 2015Trial
- Fatigue in Inflammatory Bowel Disease: The Role of Drug Therapy Within a Holistic Management Framework.Drugs · 2026Review
- Major Depressive Disorder and Serum Inflammatory Biomarkers as Predictors of Reward-Processing Dysfunction in an American Indian Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Immune markers mediate genetic relationships between immune diseases and psychiatric disorders.PLoS genetics · 2026Article
- Not always the usual suspect: symptom variations in Parkinson's disease beyond ON-OFF fluctuations.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Individualized Medication Selection and Outcome Prediction for Patients With Dementia and BPSD Based on Systemic Immune-Inflammation Index (SII): A Retrospective Case-Control Study.Actas espanolas de psiquiatria · 2026Article
- Postmortem evidence of Babesia and Bartonella infections in chronically ill suicidal young people.Parasites & vectors · 2026Article
- From Xenobiotic Exposure to Neuroinflammation: Mechanisms Linking Lipopolysaccharide Signaling to Depressive-like Behavior.Journal of xenobiotics · 2026Review
162 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Data suggest that cytokines released during the inflammatory response target subcortical structures including the basal ganglia as well as dopamine function to acutely induce behavioral changes that support fighting infection and wound healing. However, chronic inflammation and exposure to inflammatory cytokines appears to lead to persisting alterations in the basal ganglia and dopamine function reflected by anhedonia, fatigue, and psychomotor slowing. Moreover, reduced neural responses to hedonic reward, decreased dopamine metabolites in the cerebrospinal fluid and increased presynaptic dopamine uptake and decreased turnover have been described. This multiplicity of changes in the basal ganglia and dopamine function suggest fundamental effects of inflammatory cytokines on dopamine synthesis, packaging, release and/or reuptake, which may sabotage and circumvent the efficacy of current treatment approaches. Thus, examination of the mechanisms by which cytokines alter the basal ganglia and dopamine function will yield novel insights into the treatment of cytokine-induced behavioral changes and inflammatory malaise.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.