ArticleFree radical biology & medicine2012
Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection.
Article in Free radical biology & medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Insights into the Impact of Low-Dose Ionizing Radiation on Neurodegenerative Disease Progression in In Vivo Models.International journal of molecular sciences · 2026Review
- Dose-Dependent Dual Effects of Gradient Ionizing Radiation on Neurocognition.International journal of molecular sciences · 2026Review
- Mitochondrial Signaling Pathways Associated with DNA Damage Responses.International journal of molecular sciences · 2023Review
- Article
- Review
- Ionizing Radiation and Translation Control: A Link to Radiation Hormesis?International journal of molecular sciences · 2020Review
- Review
- miR-17-3p Downregulates Mitochondrial Antioxidant Enzymes and Enhances the Radiosensitivity of Prostate Cancer Cells.Molecular therapy. Nucleic acids · 2018Article
- Oxidative status of cardinal ligament in pelvic organ prolapse.Experimental and therapeutic medicine · 2018Article
- Low dose radiation prevents doxorubicin-induced cardiotoxicity.Oncotarget · 2018Article
- A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells.Cell cycle (Georgetown, Tex.) · 2017Article
- ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts.Cell cycle (Georgetown, Tex.) · 2017Article
- Radiation-Induced Oral Mucositis.Frontiers in oncology · 2017Review
- Mitochondrial reactive oxygen species-mediated genomic instability in low-dose irradiated human cells through nuclear retention of cyclin D1.Cell cycle (Georgetown, Tex.) · 2016Review
- MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer.Nature communications · 2015Article
- ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell.International journal of biological sciences · 2015Article
- Article
- Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection.Antioxidants & redox signaling · 2014Review
- MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx.Antioxidants & redox signaling · 2014Review
- Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive response.Antioxidants & redox signaling · 2014Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The cellular adaptive response to certain low-level genotoxic stresses, including exposure to low-dose ionizing radiation (LDIR), shows promise as a tool to enhance radioprotection in normal cells but not in tumor cells. Manganese superoxide dismutase (MnSOD), a fundamental mitochondrial antioxidant in mammalian cells, plays a key role in the LDIR-induced adaptive response. In this study, we aimed to elucidate the signaling network associated with MnSOD-induced radiation protection. A MnSOD-interacting protein profile was established in LDIR-treated human skin cells. Human skin keratinocytes (HK18) were irradiated with a single dose of LDIR (10 cGy X-ray) and the cell lysates were immunoprecipitated using α-MnSOD and applied to two different gel-based proteomic experiments followed by mass spectrometry for protein identification. Analysis of the profiles of MnSOD-interacting partners before and after LDIR detected various patterns of MnSOD protein-protein interactions in response to LDIR. Interestingly, many of the MnSOD-interacting proteins are known to have functions related to mitochondrial regulation of cell metabolism, apoptosis, and DNA repair. These results provide evidence indicating that in addition to the enzymatic action of detoxifying superoxide, the antioxidant MnSOD may function as a signaling regulator in stress-induced adaptive protection through cell survival pathways.
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