Evidence map›Paper›PMID 22999994›Full record

ArticleJournal of pediatric nursing

Recruitment and retention strategies in a clinical trial for children with chronic hepatitis C infection.

Aparna Roy, Whitney Lieb, Beth Garrett, Marcia Hodik, Ann Klipsch, Melissa Young, Bruce Barton, Kathleen B Schwarz

Abstract read
In one paragraph

Article in Journal of pediatric nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aparna RoyJohns Hopkins Medical Institutions, Baltimore, MD, USA.
Whitney Lieb
Beth Garrett
Marcia Hodik
Ann Klipsch
Melissa Young
Bruce Barton
Kathleen B Schwarz

Funding

Pegylated Interferon +/- Ribavirin for Children with HCVU01DK067767 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SCHWARZ, KATHLEEN · 2003 to 2008
$3.9M
NIDDK NIH HHS U01 DK067767
6 · The paper itself

Abstract

Successful strategies for recruitment and retention (R & R) in pediatric trials are needed. The purpose of our study was to analyze the effectiveness of R&R in a trial for children with hepatitis C. Recruitment strategies were (1) Initial (months 0-12) and (2) extra effort (months 13-18). Initial strategies enrolled 70/114 (61%) of patients. Extra effort strategies included: (1) radio broadcasts, (2) contact with adult hepatologists, (3) dissemination of study material and (4) modification of the exclusion criteria. The overall retention rate was 84% at 2 years. Lessons learned will be valuable in designing future pediatric trials.

Indexed as

Patient SelectionAntiviral AgentsChildHepatitis C, ChronicHumansInterferon-alphaPolyethylene GlycolsRadioRandomized Controlled Trials as TopicRecombinant ProteinsResearch DesignAntiviral AgentsInterferon-alphapeginterferon alfa-2aPolyethylene GlycolsRecombinant Proteins

Identifiers

PMID22999994
PMCPMC3540171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.