ArticleNeuroscience2012
Periaqueductal gray neuroplasticity following chronic morphine varies with age: role of oxidative stress.
Article in Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Impact of Tramadol Administration on Stomach and Duodenum of Male Rats: Histological Examinations, DNA and Biochemical Analyses.Cell biochemistry and biophysics · 2026Article
- Tramadol induces apoptosis, inflammation, and oxidative stress in rat choroid plexus.Metabolic brain disease · 2023Article
- Body size and brain volumetry in the rat following prolonged morphine administration in infancy and adulthood.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Synthesis of the Mechanisms of Opioid Tolerance: Do We Still Say NO?Cellular and molecular neurobiology · 2021Review
- Acupuncture Attenuates Blood Pressure via Inducing the Expression of nNOS.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- The molecular and biochemical insight view of lycopene in ameliorating tramadol-induced liver toxicity in a rat model: implication of oxidative stress, apoptosis, and MAPK signaling pathways.Environmental science and pollution research international · 2018Article
- Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats.BMC complementary and alternative medicine · 2018Article
- Astrocytic hypertrophy in the rat ventral tegmental area following chronic morphine differs with age.Journal of neurology and neurorehabilitation research · 2018Article
- MnSOD mediated by HSV vectors in the periaqueductal gray suppresses morphine withdrawal in rats.Gene therapy · 2017Article
- MECP2 Duplication Syndrome: Evidence of Enhanced Oxidative Stress. A Comparison with Rett Syndrome.PloS one · 2016Article
- Long-term behavioral effects in a rat model of prolonged postnatal morphine exposure.Behavioral neuroscience · 2015Article
- Endogenous cholinergic neurotransmission contributes to behavioral sensitization to morphine.PloS one · 2015Article
- Neonatal pain.Paediatric anaesthesia · 2014Review
- Effect of chronic usage of tramadol on motor cerebral cortex and testicular tissues of adult male albino rats and the effect of its withdrawal: histological, immunohistochemical and biochemical study.International journal of clinical and experimental pathology · 2014Article
- Morphine-enhanced apoptosis in selective brain regions of neonatal rats.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The development of tolerance to the antinociceptive effects of morphine has been associated with networks within ventrolateral periaqueductal gray (vlPAG) and separately, nitric oxide signaling. Furthermore, it is known that the mechanisms that underlie tolerance differ with age. In this study, we used a rat model of antinociceptive tolerance to morphine at two ages, postnatal day (PD) 7 and adult, to determine if changes in the vlPAG related to nitric oxide signaling produced by chronic morphine exposure were age-dependent. Three pharmacological groups were analyzed: control, acute morphine, and chronic morphine group. Either morphine (10mg/kg) or equal volume of normal saline was given subcutaneously twice daily for 6½ days. Animals were analyzed for morphine dose-response using Hot Plate test. The expression of several genes associated with nitric oxide metabolism was evaluated using rtPCR. In addition, the effect of morphine exposure on immunohistochemistry for Fos, and nNOS as well as nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) reaction at the vlPAG were measured. In both age groups acute morphine activated Fos in the vlPAG, and this effect was attenuated by chronic morphine, specifically in the vlPAG at the level of the laterodorsal tegmental nucleus (LDTg). In adults, but not PD7 rats, chronic morphine administration was associated with activation of nitric oxide function. In contrast, changes in the gene expression of PD7 rats suggested superoxide and peroxide metabolisms may be engaged. These data indicate that there is supraspinal neuroplasticity following morphine administration as early as PD7. Furthermore, oxidative stress pathways associated with chronic morphine exposure appear age-specific.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.