ArticleGastroenterology2013
Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
Article in Gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Variation rs9929218 and risk of the colorectal Cancer and adenomas: A meta-analysis.BMC cancer · 2021Pooled it
- Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.International journal of epidemiology · 2016Pooled it
- Common genetic variants (rs4779584 and rs10318) at 15q13.3 contributes to colorectal adenoma and colorectal cancer susceptibility: evidence based on 22 studies.Molecular genetics and genomics : MGG · 2015Pooled it
- Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility.Molecular genetics and genomics : MGG · 2015Pooled it
- Common variation rs6983267 at 8q24.1 and risk of colorectal adenoma and cancer: evidence based on 31 studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Colorectal Polyp Occurrence Associated With the ZMIZ1-AS1 rs704017 Variant and Hypertension Among Taiwan Biobank Participants.Cancer medicine · 2026Article
- Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening.British journal of cancer · 2024Article
- Immunosuppressive niche engineering at the onset of human colorectal cancer.Nature communications · 2022Article
- Genetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer.International journal of cancer · 2019Article
- Observational
- Genetic Risk Score Is Associated With Prevalence of Advanced Neoplasms in a Colorectal Cancer Screening Population.Gastroenterology · 2018Article
- Altered microRNA profiles during early colon adenoma progression in a porcine model of familial adenomatous polyposis.Oncotarget · 2017Article
- Evaluation of genetic variants in association with colorectal cancer risk and survival in Asians.International journal of cancer · 2017Article
- Risk of eighteen genome-wide association study-identified genetic variants for colorectal cancer and colorectal adenoma in Han Chinese.Oncotarget · 2016Article
- Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia.Medicine · 2016Observational
- Colorectal cancer risk variants at 8q23.3 and 11q23.1 are associated with disease phenotype in APC mutation carriers.Familial cancer · 2016Article
- Clinical features of Hispanic thyroid cancer cases and the role of known genetic variants on disease risk.Medicine · 2016Article
- The HABP2 G534E variant is an unlikely cause of familial non-medullary thyroid cancer.The Journal of clinical endocrinology and metabolism · 2016Article
- Article
- Impaired fasting glucose, single-nucleotide polymorphisms, and risk for colorectal cancer in Koreans.Epidemiology and health · 2016Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 4 countries.
Funding
Abstract
Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, rs1957636, rs4939827, and rs961253) were over-represented in CRC-free patients with adenomas, compared with controls. Ten other CRC-associated SNPs (rs6691170, rs6687758, rs16892766, rs7136702, rs11169552, rs4779584, rs9929218, rs10411210, rs4813802, and rs4925386) were not associated significantly with adenoma risk. Genetic susceptibility to CRC in the general population is likely to be mediated in part by predisposition to adenomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.