ArticleJournal of molecular biology2012
The right angle (RA) motif: a prevalent ribosomal RNA structural pattern found in group I introns.
Article in Journal of molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM.Nature communications · 2023Article
- In vitro selected GUAA tetraloop-binding receptors with structural plasticity and evolvability towards natural RNA structural modules.Nucleic acids research · 2021Article
- Modulating Immune Response with Nucleic Acid Nanoparticles.Molecules (Basel, Switzerland) · 2019Review
- Responsive self-assembly of tectoRNAs with loop-receptor interactions from the tetrahydrofolate (THF) riboswitch.Nucleic acids research · 2019Article
- Deducing putative ancestral forms of GNRA/receptor interactions from the ribosome.Nucleic acids research · 2019Article
- A metastable rRNA junction essential for bacterial 30S biogenesis.Nucleic acids research · 2018Article
- Composing RNA Nanostructures from a Syntax of RNA Structural Modules.Nano letters · 2017Article
- Versatile RNA tetra-U helix linking motif as a toolkit for nucleic acid nanotechnology.Nanomedicine : nanotechnology, biology, and medicine · 2017Article
- RNA quaternary structure and global symmetry.Trends in biochemical sciences · 2015Review
- Engineered RNA Nanodesigns for Applications in RNA Nanotechnology.DNA and RNA nanotechnology · 2015Article
- Annotating RNA motifs in sequences and alignments.Nucleic acids research · 2015Article
- Article
- Network Theory Tools for RNA Modeling.WSEAS transactions on mathematics · 2013Article
- RNA modularity for synthetic biology.F1000prime reports · 2013Review
- The GA-minor submotif as a case study of RNA modularity, prediction, and design.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The right angle (RA) motif, previously identified in the ribosome and used as a structural module for nano-construction, is a recurrent structural motif of 13 nucleotides that establishes a 90° bend between two adjacent helices. Comparative sequence analysis was used to explore the sequence space of the RA motif within ribosomal RNAs in order to define its canonical sequence space signature. We investigated the sequence constraints associated with the RA signature using several artificial self-assembly systems. Thermodynamic and topological investigations of sequence variants associated with the RA motif in both minimal and expanded structural contexts reveal that the presence of a helix at the 3' end of the RA motif increases the thermodynamic stability and rigidity of the resulting three-helix junction domain. A search for the RA in naturally occurring RNAs as well as its experimental characterization led to the identification of the RA in groups IC1 and ID intron ribozymes, where it is suggested to play an integral role in stabilizing peripheral structural domains. The present study exemplifies the need of empirical analysis of RNA structural motifs for facilitating the rational design and structure prediction of RNAs.
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