ArticleCell reports2012
Regulating contractility of the actomyosin cytoskeleton by pH.
Article in Cell reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- The effects of pH on cortex and condensate formation.The Journal of cell biology · 2026Article
- Optimal neuromuscular performance requires motor neuron phosphagen kinases.The Journal of physiology · 2026Article
- pH-regulated single cell migration.Pflugers Archiv : European journal of physiology · 2024Review
- Cofilin-mediated actin filament network flexibility facilitates 2D to 3D actomyosin shape change.European journal of cell biology · 2024Article
- pH regulates hematopoietic stem cell potential via polyamines.EMBO reports · 2023Article
- Partial exogastrulation due to apical-basal polarity of F-actin distribution disruption in sea urchin embryo by omeprazole.Genes to cells : devoted to molecular & cellular mechanisms · 2022Article
- Article
- Machine learning based approach to pH imaging and classification of single cancer cells.APL bioengineering · 2021Article
- Bioelectrical and cytoskeletal patterns correlate with altered axial polarity in the follicular epithelium of the Drosophila mutant gurken.BMC developmental biology · 2020Article
- Electrochemical gradients are involved in regulating cytoskeletal patterns during epithelial morphogenesis in the Drosophila ovary.BMC developmental biology · 2019Article
- Scaling behaviour in steady-state contracting actomyosin networks.Nature physics · 2019Article
- Trabecular Meshwork TREK-1 Channels Function as Polymodal Integrators of Pressure and pH.Investigative ophthalmology & visual science · 2019Article
- Self-organized stress patterns drive state transitions in actin cortices.Science advances · 2018Article
- Triggering signaling pathways using F-actin self-organization.Scientific reports · 2016Article
- Shape remodeling and blebbing of active cytoskeletal vesicles.Science advances · 2016Article
- Forcing cells into shape: the mechanics of actomyosin contractility.Nature reviews. Molecular cell biology · 2015Review
- Article
- Ion channels and transporters in tumour cell migration and invasion.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Electrostatics control actin filament nucleation and elongation kinetics.The Journal of biological chemistry · 2013Article
- Intracellular Acidification Suppresses Synaptic Vesicle Mobilization in the Motor Nerve Terminals.Acta naturaeArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The local interaction of F-actin with myosin-II motor filaments and crosslinking proteins is crucial for the force generation, dynamics, and reorganization of the intracellular cytoskeleton. By using a bottom-up approach, we are able to show that the contractility of reconstituted active actin systems is tightly controlled by the local pH. The pH-dependent intrinsic crossbridge strength of myosin-II is identified to account for a sharp transition of the actin/myosin-II activity from noncontractile to contractile by a change in pH of only 0.1. This pH-dependent contractility is a generic feature, which is observed in all studied crosslinked actin/myosin-II systems. The specific type and concentration of crosslinking protein allows one to sensitively adjust the range of pH where contraction occurs, which can recover the behavior found in Xenopus laevis oocyte extracts. Small variations in pH provide a mechanism of controlling the contractility of cytoskeletal structures, which can be expected to have broad implications in our understanding of cytoskeletal regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.