ArticleRespiratory physiology & neurobiology2013
Focal microdialysis of CO₂ in the perifornical-hypothalamic area increases ventilation during wakefulness but not NREM sleep.
Article in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Hypothalamic Glutamatergic/Orexinergic Neurons Attenuate Fentanyl-Induced Respiratory Depression via Medullary Pre-BöTzinger Complex Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Galaninergic and hypercapnia-activated neuronal projections to the ventral respiratory column.Brain structure & function · 2024Article
- Review
- The effect of orexin on the hypoxic ventilatory response of female rats is greatest in the active phase during diestrus.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- ACE2 in male genitourinary and endocrine systems: Does COVID-19 really affect these systems?Histology and histopathology · 2023Review
- The effects of P2YFrontiers in physiology · 2023Article
- Criteria for central respiratory chemoreceptors: experimental evidence supporting current candidate cell groups.Frontiers in physiology · 2023Review
- COBrain structure & function · 2022Article
- Central respiratory chemoreception.Handbook of clinical neurology · 2022Review
- Forebrain control of breathing: Anatomy and potential functions.Frontiers in neurology · 2022Review
- Review
- Post-ictal Generalized EEG Suppression is reduced by Enhancing Dorsal Raphe Serotonergic Neurotransmission.Neuroscience · 2021Article
- Orexin Neurons Contribute to Central Modulation of Respiratory Drive by Progestins onFrontiers in physiology · 2019Article
- Orexinergic system in the locus coeruleus modulates the CO2 ventilatory response.Pflugers Archiv : European journal of physiology · 2016Article
- Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function.Acta physiologica (Oxford, England) · 2015Article
- Hypoxia silences retrotrapezoid nucleus respiratory chemoreceptors via alkalosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The orexinergic neurons receive synaptic input from C1 cells in rats.The Journal of comparative neurology · 2014Article
- Regulation of breathing and autonomic outflows by chemoreceptors.Comprehensive Physiology · 2014Review
- Article
- Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control.Physiology & behavior · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We investigated whether the perifornical-lateral hypothalamic area (PF-LHA), where the orexin neurons reside, is a central chemoreceptor site by microdialysis of artificial cerebrospinal fluid (aCSF) equilibrated with 25% CO(2) into PF-LHA in conscious rats. This treatment is known to produce a focal tissue acidification like that associated with a 6-7 mm Hg increase in arterial [Formula: see text] . Such focal acidification in the PF-LHA significantly increased ventilation up to 15% compared with microdialysis of normal aCSF equilibrated with 5% CO(2) only in wakefulness but not in sleep in both the dark (P=0.004) and light (P<0.001) phases of the diurnal cycle. This response was predominantly due to a significant increase in respiratory frequency (11%, P<0.001). There were no significant effects on ventilation in the group with probes misplaced outside the PF-LHA. These results suggest that PF-LHA functions as a central chemoreceptor site in the central nervous system in a vigilant state dependent manner with predominant effects in wakefulness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.