ArticleJournal of the American Medical Directors Association2012
Novel risk markers and long-term outcomes of delirium: the successful aging after elective surgery (SAGES) study design and methods.
Article in Journal of the American Medical Directors Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 2 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Incidence and Risk Factors for Postoperative Delirium in Patients Undergoing Spine Surgery: A Systematic Review and Meta-Analysis.BioMed research international · 2019Pooled it
- Consensus Approaches to Identify Incident Dementia in Cohort Studies: Systematic Review and Approach in the Successful Aging after Elective Surgery Study.Journal of the American Medical Directors Association · 2017Pooled it
- Cognitive Outcomes After Hip Fracture Surgery: The Association of Postoperative Delirium on Previously Cognitively Normal Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Trial
- Detection of postoperative delirium by family and caregivers: Evaluation of the family confusion assessment method (FAM-CAM).Journal of clinical anesthesia · 2025Trial
- Use of the confusion assessment method in multicentre delirium trials: training and standardisation.BMC geriatrics · 2019Trial
- Rehospitalization and the Association of Postoperative Delirium With Cognitive Decline in Older Adults.JAMA internal medicine · 2026Article
- Cognitive Trajectories After Major Surgery in Older Adults and Factors Associated With Severe Decline.Journal of the American Geriatrics Society · 2026Article
- A Multimodal Approach for Study Diagnosis of MCI and Dementia in the Successful Aging After Elective Surgery (SAGES) Cohort.The American journal of geriatric psychiatry. Open science, education, and practice · 2026Article
- The Influence of Pharmacological Agents Used During General Anesthesia on the Intensity of Postoperative Pain and the Occurrence of Post-Anesthetic Delirium-A Scoping Review.Journal of clinical medicine · 2026Review
- Development and Implementation of a Radiation Safety Screening Protocol for a Clinical Study Using Amyloid Positron Emission Tomography Imaging.Ochsner journal · 2026Article
- Information and Counseling Gaps on Perioperative Neurocognitive Disorders Among Older Adults.Journal of the American Geriatrics Society · 2025Article
- Perioperative complications and postoperative outcome of primary total knee arthroplasty in octogenarians - A systematic review.Journal of orthopaedics · 2025Review
- Adaptation, calibration, and validation of a cognitive assessment battery for telephone and video administration.Journal of the American Geriatrics Society · 2025Observational
- Predilection for Perplexion: Preoperative microstructural damage is linked to postoperative delirium.medRxiv : the preprint server for health sciences · 2025Article
- Multi-level social determinants of health, inflammation, and postoperative delirium in older adults.Journal of the American Geriatrics Society · 2025Article
- Inflammatory Indices and Their Associations With Postoperative Delirium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium.BJA open · 2024Article
- Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients.Neurobiology of aging · 2024Article
- A machine learning-based prediction model for postoperative delirium in cardiac valve surgery using electronic health records.BMC cardiovascular disorders · 2024Article
- Successful aging after elective surgery II: Study cohort description.Journal of the American Geriatrics Society · 2024Observational
49 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesDelirium, a costly, life-threatening, and potentially preventable condition, is a common complication for older adults following major surgery. Although the basic epidemiology of delirium after surgery has been defined, the contribution of delirium to long term outcomes remains uncertain, and novel biomarkers from plasma and neuroimaging have yet to be examined. This program project was designed to contribute to our understanding of the complex multifactorial syndrome of delirium.
designLong term prospective cohort study.
settingThree academic medical centers (2 hospitals and 1 coordinating center).
participantsPatients without recognized dementia (targeted cohort= 550 patients) age 70 and older scheduled to undergo elective major surgery are assessed at baseline before surgery, daily during their hospital stay, and for 18 to 36 months after discharge. MEASUREMENTS: The Successful Aging after Elective Surgery (SAGES) study is an innovative, interdisciplinary study that includes biomarkers, neuroimaging, cognitive reserve markers, and serial neuropsychological testing to examine the contribution of delirium to long term cognitive and functional decline. The primary goal is to examine the contribution of delirium to long term cognitive and functional decline. In addition, novel risk markers for delirium are being examined, including plasma biomarkers (eg, cytokines, proteomics), advanced neuroimaging markers (eg, volumetric, white matter hyperintensity, noncontrast blood flow, and diffusion tensor measures), and cognitive reserve markers (eg, education, occupation, lifetime activities).
conclusionResults from this study will contribute to a fuller understanding of the etiology and prognosis of delirium. Ultimately, we hope this project will provide the groundwork for future development of prevention and treatment strategies for delirium, designed to minimize the long term negative impact of delirium in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.