ArticleACS chemical biology2012
Rapidly relocating molecules between organelles to manipulate small GTPase activity.
Article in ACS chemical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Technologies to measure and modulate protein subcellular localization.Nature reviews. Molecular cell biology · 2026Review
- Methods for Controlling Small GTPase Activity.Chembiochem : a European journal of chemical biology · 2025Review
- Review
- Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells.Small GTPases · 2019Review
- Multidirectional Activity Control of Cellular Processes by a Versatile Chemo-optogenetic Approach.Angewandte Chemie (International ed. in English) · 2018Article
- Synthesis and biological evaluation of rapamycin-derived, next generation small molecules.MedChemComm · 2018Review
- Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells.ACS central science · 2016Article
- Article
- Article
- A method to rapidly induce organelle-specific molecular activities and membrane tethering.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Rapidly reversible manipulation of molecular activity with dual chemical dimerizers.Angewandte Chemie (International ed. in English) · 2013Article
- Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology.Pflugers Archiv : European journal of physiology · 2013Review
- Using a kinase-inducible bimolecular switch to control enzyme activity in living cells.Current protocols in chemical biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Chemically inducible rapid manipulation of small GTPase activity has proven a powerful approach to dissect complex spatiotemporal signaling of these molecular switches. However, overexpression of these synthetic molecular probes freely in the cytosol often results in elevated background activity before chemical induction, which perturbs the cellular basal state and thereby limits their wide application. As a fundamental solution, we have rationally designed and newly developed a strategy to remove unwanted background activity without compromising the extent of induced activation. By exploiting interaction between a membrane lipid and its binding protein, target proteins were translocated from one organelle to another on a time scale of seconds. This improved strategy now allows for rapid manipulation of small GTPases under a physiological state, thus enabling fine dissection of sophisticated signaling processes shaped by these molecules.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.