Evidence map›Paper›PMID 22999332›Full record

ArticleDiagnostic microbiology and infectious disease2012

Rapid identification of pathogens from positive blood cultures by multiplex polymerase chain reaction using the FilmArray system.

Anne J Blaschke, Caroline Heyrend, Carrie L Byington, Mark A Fisher, Elizabeth Barker, Nicholas F Garrone, Stephanie A Thatcher, Andrew T Pavia, Trenda Barney, Garrison D Alger and 4 more

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 202 citations in OpenAlex.

  1. Randomized Trial of Rapid Multiplex Polymerase Chain Reaction-Based Blood Culture Identification and Susceptibility Testing.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Anne J BlaschkeDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA. anne.blaschke@hsc.utah.edu
Caroline Heyrend
Carrie L Byington
Mark A Fisher
Elizabeth Barker
Nicholas F Garrone
Stephanie A Thatcher
Andrew T Pavia
Trenda Barney
Garrison D Alger
Judy A Daly
Kirk M Ririe
Irene Ota
Mark A Poritz
University of Utah · USPrimary Children's Hospital · USUniversity Pathologists · US

Funding

UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
HT-Film-Array: a system to assess respiratory viruses with emphasis on influenzaU01AI074419 · NIAID · BIOFIRE DEFENSE, LLC. · PI PORITZ, MARK AARON · 2007 to 2011
$8.2M
STI and Respiratory Pathogen testing in nontraditional settingsU01AI082482 · NIAID · BIOFIRE DEFENSE, LLC. · PI BYINGTON, CARRIE L., CRISP, ROBERT JOHN · 2009 to 2012
$3.5M
FilmArray Biothreat Pathogens: An Automated Multiplex PCR Diagnostic SystemU01AI082184 · NIAID · BIOFIRE DEFENSE, LLC. · PI OTA, IRENE M · 2009 to 2010
$3.0M
Epidemiology and Etiology of Hospitalized Pneumonia in ChildrenU18IP000303 · IP · UNIVERSITY OF UTAH · PI AMPOFO, KROW · 2009 to 2010
$1.6M
Decision Support for Evaluation of the Febrile InfantK24HD047249 · NICHD · UNIVERSITY OF UTAH · PI BYINGTON, CARRIE L. · 2005 to 2009
$617k
Rapid Molecular Testing for Neonatal Antibiotic-Resistant PathogensK23AI079401 · NIAID · UNIVERSITY OF UTAH · PI BLASCHKE, ANNE J. · 2009 to 2012
$549k
NCIRD CDC HHS 1U18IP000303NCIRD CDC HHS U18 IP000303NCRR NIH HHS UL1 RR025764NCRR NIH HHS UL1RR025764NIAID NIH HHS 1K23AI079401NIAID NIH HHS 1U01AI074419NIAID NIH HHS 1U01AI082184NIAID NIH HHS 1U01AI082482NIAID NIH HHS K23 AI079401NIAID NIH HHS U01 AI074419NIAID NIH HHS U01 AI082184NIAID NIH HHS U01 AI082482NICHD NIH HHS K24 HD047249NICHD NIH HHS K24HD047249PHS HHS U01A1061611
6 · The paper itself

Abstract

Sepsis is a leading cause of death. Rapid and accurate identification of pathogens and antimicrobial resistance directly from blood culture could improve patient outcomes. The FilmArray® (FA; Idaho Technology, Salt Lake City, UT, USA) Blood Culture (BC) panel can identify >25 pathogens and 4 antibiotic resistance genes from positive blood cultures in 1 h. We compared a development version of the panel to conventional culture and susceptibility testing on 102 archived blood cultures from adults and children with bacteremia. Of 109 pathogens identified by culture, 95% were identified by FA. Among 111 prospectively collected blood cultures, the FA identified 84 (91%) of 92 pathogens covered by the panel. Among 25 Staphylococcus aureus and 21 Enterococcus species detected, FA identified all culture-proven methicillin-resistant S. aureus and vancomycin-resistant enterococci. The FA BC panel is an accurate method for the rapid identification of pathogens and resistance genes from blood culture.

Indexed as

AdultBacteremiaBacteriaBacteriological TechniquesBloodChildChild, PreschoolDrug Resistance, BacterialHumansMultiplex Polymerase Chain Reaction

Identifiers

PMID22999332
PMCPMC3496814
OpenAlexW2136835433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.