ReviewHeart failure clinics2012
Insulin resistance and heart failure: molecular mechanisms.
Review in Heart failure clinics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
161 citing papers in PubMed, 4 syntheses or guidelines pooled it, 251 citations in OpenAlex.
- Triglyceride-glucose index and the prognosis of patients with heart failure: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- A meta-analysis of the prognostic value of the TyG index in heart failure.Frontiers in endocrinology · 2025Pooled it
- Using multi-omics to explore the genetic causal relationship between colorectal cancer and heart failure in gastrointestinal tumors.Frontiers in immunology · 2024Pooled it
- Insulin resistance and incident heart failure: a meta-analysis.European journal of heart failure · 2022Pooled it
- Trial
- Machine learning-based prediction model for predicting the impact of insulin resistance on the risk of ischemic cardiomyopathy.BMC medical informatics and decision making · 2026Article
- Prognostic value of C-reactive protein-triglyceride-glucose index in hospitalised patients with acute decompensated heart failure.BMC cardiovascular disorders · 2026Article
- Retinol-binding Protein 4 as a Predictor of Cardiovascular Events after Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction.Journal of atherosclerosis and thrombosis · 2026Article
- Association of Triglyceride-Glucose Index with Negative Clinical Outcomes in Geriatric Patients with Chronic Heart Failure.Journal of clinical medicine · 2026Article
- Glucose Disposal Rate: A Novel Measure of Insulin Resistance Associated With Myocardial Fibrosis and Incident Heart Failure.Journal of the American Heart Association · 2026Article
- Angiographic Burden of Coronary Atherosclerosis Partially Mediates the Association Between ASCVD Risk Factors and Outcomes.Circulation. Genomic and precision medicine · 2026Article
- Metabolic syndrome and a broken heart: trust your gut or risk your heart.American journal of physiology. Heart and circulatory physiology · 2026Review
- Association between estimated glucose disposal rate and incident heart failure in patients with coronary heart disease: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Predictive value of an integrated insulin resistance and lipometabolic score for cardiometabolic multimorbidity in older adults: a UK cohort study.Cardiovascular diabetology · 2026Article
- Review on the Relationship Between TyG Index and CVD Incidence in Patients With T2DM With NAFLD.International journal of endocrinology · 2026Review
- Association between triglyceride-glucose index and heart failure in patients with type 2 diabetes mellitus: a cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Remnant cholesterol inflammation index as a predictor of mortality in patients with acute decompensated heart failure: evidence from the Jiangxi, China cohort.Frontiers in endocrinology · 2026Article
- Cellular and Molecular Pathways in Diabetes-Associated Heart Failure: Emerging Mechanistic Insights and Therapeutic Opportunities.Current issues in molecular biology · 2025Review
- The Contribution of Echocardiography to the Diagnosis and Prognosis Stratification of Diabetic Cardiomyopathy.Diagnostics (Basel, Switzerland) · 2025Review
- New insights into the role of metallothioneins in obesity and diabetes.International journal of obesity (2005) · 2025Review
101 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
This article addresses the issue of insulin resistance and associated reductions in cardiac insulin metabolic signaling, which is emerging as a major factor in the development of heart failure, and assumes more importance because of an epidemic increase in obesity and the cardiorenal metabolic syndrome in our aging population. The effects of cardiac insulin resistance are exacerbated by metabolic, endocrine, and cytokine alterations associated with systemic insulin resistance. Understanding the molecular mechanisms linking insulin resistance and heart failure may help to design new and more effective mechanism-based drugs to improve myocardial and systemic insulin resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.