Trial reportCardiovascular diabetology2012
Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial.
Trial report in Cardiovascular diabetology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00366990 (Clinical Trial to Reverse Early Arterial Stiffening), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Trial to Reverse Early Arterial Stiffening
Who cites it
29 citing papers in PubMed, 66 citations in OpenAlex.
- The effect of exercise training level on arterial stiffness after clinically significant weight loss.Clinical obesity · 2023Trial
- Exercise effects on arterial stiffness and heart health in children with excess weight: The SMART RCT.International journal of obesity (2005) · 2020Trial
- Vasodilatory Actions of Glucagon-Like Peptide 1 Are Preserved in Skeletal and Cardiac Muscle Microvasculature but Not in Conduit Artery in Obese Humans With Vascular Insulin Resistance.Diabetes care · 2020 · on this mapTrial
- Regaining body weight after weight reduction further increases pulse wave velocity in obese men with metabolic syndrome.Medicine · 2018Trial
- Effects of Resistance Training With and Without Caloric Restriction on Arterial Stiffness in Overweight and Obese Older Adults.American journal of hypertension · 2016Trial
- Weight reduction and aortic stiffness in obese children and adolescents: a 1-year follow-up study.Journal of human hypertension · 2015Trial
- Neck circumference and early stage atherosclerosis: the cardiometabolic risk in Chinese (CRC) study.Cardiovascular diabetology · 2014Trial
- Arterial stiffness and β-amyloid progression in nondemented elderly adults.JAMA neurology · 2014Trial
- The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus.Cardiovascular diabetology · 2014 · on this mapTrial
- Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.Neurology · 2013Trial
- The synergistic effect of the triglyceride-glucose index and a body shape index on cardiovascular mortality: the construction of a novel cardiovascular risk marker.Cardiovascular diabetology · 2025Article
- Shared Genetic Architectures between Coronary Artery Disease and Type 2 Diabetes Mellitus in East Asian and European Populations.Biomedicines · 2024Article
- Association between weight-adjusted waist index and arterial stiffness in hypertensive patients: The China H-type hypertension registry study.Frontiers in endocrinology · 2023Article
- Review
- Change in triglyceride-glucose index predicts the risk of cardiovascular disease in the general population: a prospective cohort study.Cardiovascular diabetology · 2021Observational
- Letter: Effects of 6 Months of Dapagliflozin Treatment on Metabolic Profile and Endothelial Cell Dysfunction for Obese Type 2 Diabetes Mellitus Patients without Atherosclerotic Cardiovascular Disease (J Obes Metab Syndr 2020;29:215-21).Journal of obesity & metabolic syndrome · 2021Article
- Evaluation of the associations of body height with blood pressure and early-stage atherosclerosis in Chinese adults.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Arterial stiffness and hypertension status in Afro-Caribbean men.Journal of hypertension · 2019Article
- Glycated hemoglobin correlates with arterial stiffness and endothelial dysfunction in patients with resistant hypertension and uncontrolled diabetes mellitus.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Strategies for Achieving Healthy Vascular Aging.Hypertension (Dallas, Tex. : 1979) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic arterial stiffness contributes to the negative health effects of obesity and insulin resistance, which include hypertension, stroke, and increased cardiovascular and all-cause mortality. Weight loss and improved insulin sensitivity are individually associated with improved central arterial stiffness; however, their combined effects on arterial stiffness are poorly understood. The purpose of this study was to determine how insulin levels modify the improvements in arterial stiffness seen with weight loss in overweight and obese young adults.
methodsTo assess the effects of weight loss and decreased fasting insulin on vascular stiffness, we studied 339 participants in the Slow the Adverse Effects of Vascular Aging (SAVE) trial. At study entry, the participants were aged 20-45, normotensive, non-diabetic, and had a body-mass index of 25-39.9 kg/m2. Measures of pulse wave velocity (PWV) in the central (carotid-femoral (cfPWV)), peripheral (femoral-ankle (faPWV)), and mixed (brachial-ankle (baPWV)) vascular beds were collected at baseline and 6 months. The effects of 6-month change in weight and insulin on measures of PWV were estimated using multivariate regression.
resultsAfter adjustment for baseline risk factors and change in systolic blood pressure, 6-month weight loss and 6-month change in fasting insulin independently predicted improvement in baPWV but not faPWV or cfPWV. There was a significant interaction between 6-month weight change and change in fasting insulin when predicting changes in baPWV (p < 0.001). Individuals experiencing both weight loss and insulin reductions showed the greatest improvement in baPWV.
conclusionsYoung adults with excess weight who both lower their insulin levels and lose weight see the greatest improvement in vascular stiffness. This improvement in vascular stiffness with weight loss and insulin declines may occur throughout the vasculature and may not be limited to individual vascular beds.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.