Evidence map›Paper›PMID 22998525›Full record

SynthesisDevelopmental medicine and child neurology2013

The effect of pediatric traumatic brain injury on behavioral outcomes: a systematic review.

Linda Li, Jianghong Liu

Abstract readSystematic Review
In one paragraph

Synthesis in Developmental medicine and child neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  19. The impact of adolescent traumatic brain injury on health risk behaviors.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2025
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Linda LiSchool of Nursing, University of Pennsylvania, Philadelphia, PA 19104-4217, USA.
Jianghong Liu

Funding

Lead exposure, externalizing behavior, and neurobiological mediating factorsR01ES018858 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG · 2010 to 2014
$1.7M
Mechanisms that mediate the link between lead exposure and child behavior problemK02ES019878 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG · 2011 to 2015
$656k
Environmental Toxicity, Malnutrition, and Children's Externalizing BehaviorK01ES015877 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIU, JIANGHONG · 2007 to 2010
$605k
NIEHS NIH HHS K01 ES015877NIEHS NIH HHS K01-ES015877NIEHS NIH HHS K02 ES019878NIEHS NIH HHS R01 ES018858NIEHS NIH HHS R01-ES018858
6 · The paper itself

Abstract

aimTo review systematically the empirical evidence on traumatic brain injury (TBI) during childhood and subsequent behavioral problems.

methodAn initial literature search with keywords 'brain injury,''children,' and 'behavior' was conducted using Web of Knowledge and PubMed databases. Ancestry was also used. Original research studies published between 1990 and February 2012 focusing on behavioral outcomes of children sustaining TBI from ages 0 to 18 years were included.

resultsFifty studies, varying considerably in methodologies, were included in the review. Findings showed that up to 50% of brain-injured children are at risk for presenting with specific behavioral problems and disorders. These problems may emerge shortly or several years after injury and often persist and even worsen with time. These behavioral impairments appear to be moderated by the family environment.

interpretationSurvivors of childhood TBI are at risk for developing and sustaining behavioral impairments. Stronger research is needed to identify cognitive and environmental factors that contribute to the onset and maintenance of these problems. Healthcare providers should ensure adequate follow-up and assessment of a child's behavioral, social, and neurocognitive domains. Caregivers should be encouraged to provide positive environments and parenting styles, which may help reduce chronic behavioral problems after brain injury.

Indexed as

PediatricsAdolescentBrain InjuriesChildChild Behavior DisordersChild, PreschoolDatabases, FactualHumansInfantInfant, Newborn

Identifiers

PMID22998525
PMCPMC3593091

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.