SynthesisBMC neurology2012
Endovascular coiling versus neurosurgical clipping in patients with unruptured intracranial aneurysm: a systematic review.
Synthesis in BMC neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Preventive clipping versus coiling in unruptured intracranial aneurysms: A comprehensive meta-analysis and systematic review to explore safety and efficacy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Pooled it
- Comparative Effectiveness of Surgical, Endovascular, and Conservative Strategies for Unruptured Intracranial Aneurysms.Stroke (Hoboken, N.J.) · 2026Article
- A large peri-aneurysmal cyst formation following coil embolization of an unruptured middle cerebral artery aneurysm: A case report and review of the literature.Surgical neurology international · 2026Article
- Clipping of Unruptured Intracranial Aneurysm via Various Keyhole Mini-craniotomy Procedures: Substantial Curability and Psychological Comfort in 350 Cases over 20 Years.Neurologia medico-chirurgica · 2025Article
- Could MR Angio Replace Digital Subtraction Angiography for Verification of Occlusion Rate of Cerebral Aneurysms?Journal of clinical medicine · 2025Article
- Hospital readmission among patients with unruptured intracranial aneurysms undergoing stent-assisted endovascular coiling using the ENTERPRISEJournal of comparative effectiveness research · 2025Article
- Balloon inflation predicts recanalization of intracranial aneurysms treated with coiling alone.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- A novel histological occlusion classification for coiled aneurysms based on multiphoton microscopy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Impact Exploration of Spatiotemporal Feature Derivation and Selection on Machine Learning-Based Predictive Models for Post-Embolization Cerebral Aneurysm Recanalization.Cardiovascular engineering and technology · 2024Article
- The Usefulness of Extradural Anterior Clinoidectomy for Lower-Lying Posterior Communicating Artery Aneurysms : A Cadaveric Study.Journal of Korean Neurosurgical Society · 2024Article
- A 5-Year Follow-Up after Endovascular Treatment of 402 Intracranial Aneurysms-A Single-Centre Experience.Biomedicines · 2024Article
- Ticagrelor versus clopidogrel in stent-assisted coil embolization of unruptured intracranial aneurysms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022Article
- Outpatient Day-Care Management of Unruptured Intracranial Aneurysm: A Retrospective Cohort Study.Korean journal of radiology · 2022Article
- Prediction of postoperative motor deficits using intraoperative motor-evoked potentials in middle cerebral artery aneurysm.Neurosurgical review · 2021Article
- National Trends in the Treatment of Ruptured Cerebral Aneurysms in Korea Using an Age-adjusted Method.Journal of Korean medical science · 2020Article
- Clinical and morphological risk factors for the recurrence of anterior communicating artery aneurysms after clipping or coiling.Acta neurochirurgica · 2020Article
- Perioperative Ischemic Stroke in Unruptured Intracranial Aneurysm Surgical or Endovascular Therapy.Cureus · 2020Article
- Coil Embolization for Unruptured Intracranial Aneurysms at the Dawn of Stent Era: Results of the Japanese Registry of Neuroendovascular Therapy (JR-NET) 3.Neurologia medico-chirurgica · 2020Article
- Clinical Pharmacology of Clazosentan, a Selective Endothelin A Receptor Antagonist for the Prevention and Treatment of aSAH-Related Cerebral Vasospasm.Frontiers in pharmacology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo compare the effects of endovascular coiling and neurosurgical clipping in patients with unruptured intracranial aneurysm.
methodsSixteen electronic databases were searched for articles published between 1950 and July 2010 to compare clinical outcomes of clipping and coiling. Researchers reviewed all searched articles and extracted data independently. The quality of studies and evidence were evaluated using MINORS and GRADEprofiler, respectively. The odds ratio (OR) was calculated using the inverse variance meta-analysis method for each study outcome. To assess heterogeneity of ORs across cohorts, Cochran's Q statistic and I² were used.
resultsOf 4160 studies, 24 were identified (n = 31865). Clipping resulted in significantly higher disability using the Glasgow Outcome Scale (OR, 2.38; 95% CI, 1.33-4.26) and Modified Rankin Scale (OR, 2.83; 95% CI, 1.42-5.63) when compared with coiling. ORs for complications were also higher with clipping (ORs for neurological and cardiac complications were 1.94 with a 95% confidence interval [CI] of 1.09-3.47 and 2.51 with a 95% CI of 1.15-5.50). Clipping resulted in significantly greater disability in the short term (≤6 m)(OR on the Glasgow Outcome Scale, 2.72; 95% CI, 1.16-6.34), but not in the long term (>6 m)(OR for Glasgow Outcome Scale, 2.12; 95% CI, 0.93-4.84).
conclusionsCoiling was a better procedure for treatment of unruptured intracranial aneurysm in terms of disability, complications, especially in the short term. Because of the limitations of the reviewed studies, further studies are required to support the present results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.