Evidence map›Paper›PMID 22998126›Full record

ArticleActa neurologica Scandinavica2013

Selecting anti-epileptic drugs: a pediatric epileptologist's view, a computer's view.

J Pestian, P Matykiewicz, K Holland-Bouley, S Standridge, M Spencer, T Glauser

Abstract read
In one paragraph

Article in Acta neurologica Scandinavica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Management of childhood epilepsy.Continuum (Minneapolis, Minn.) · 2013
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

J PestianDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. john.pestian@cchmc.org
P Matykiewicz
K Holland-Bouley
S Standridge
M Spencer
T Glauser
Cincinnati Children's Hospital Medical Center · USIn-Q-Tel · US

Funding

Impact of Initial Therapy and Response on Long Term Outcome in Children with CAEU01NS045911 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI GLAUSER, TRACY A · 2003 to 2013
$31.1M
Sodium Channel Gene Variation in the Treatment of EpilepsyR01NS062756 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI HOLLAND, KATHERINE D · 2009 to 2013
$1.6M
Multi-Institutional Pediatric Epilepsy Decision SupportR01LM011124 · NLM · CINCINNATI CHILDRENS HOSP MED CTR · PI PESTIAN, JOHN P · 2011 to 2013
$955k
NINDS NIH HHS NS045911NINDS NIH HHS R01 NS062756NINDS NIH HHS U01 NS045911NLM NIH HHS R01 LM011124
6 · The paper itself

Abstract

objectiveTo identify which clinical characteristics are important to include in clinical decision support systems developed for Antiepileptic Drug (AEDs) selection.

methodsTwenty-three epileptologists from the Childhood Absence Epilepsy network completed a survey related to AED selection. Using cluster analysis their responses where classified into subject matter groups and weighted for importance.

resultsFive distinct subject matter groups were identified and their relative weighting for importance were determined: disease characteristics (weight 4.8 ± 0.049), drug toxicities (3.82 ± 0.098), medical history (3.12 ± 0.102), systemic characteristics (2.57 ± 0.048) and genetic characteristics (1.08 ± 0.046).

conclusionResearch about prescribing patterns exists but research on how such data can be used to train advanced technology is novel. As machine learning algorithms becomes more and more prevalent in clinical decisions support systems, developing methods for determining which data should be part of those algorithms is equally important.

Indexed as

AlgorithmsArtificial IntelligenceDecision Support Systems, ClinicalAnticonvulsantsCluster AnalysisEpilepsyFemaleHumansMalePhysiciansPractice Patterns, Physicians'Anticonvulsants

Identifiers

PMID22998126
PMCPMC3574228
OpenAlexW1987176315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.