ArticleScientific reports2012
COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Mental Roots of Performance: A Preliminary Meta-Analysis of Cognitive Genes and Athlete Status.Molecular neurobiology · 2025Pooled it
- Importance of the dysregulation of the kynurenine pathway on cognition in schizophrenia: a systematic review of clinical studies.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Catechol-Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dopaminergic Genetic Variation and Trait Impulsivity: The Role ofLife (Basel, Switzerland) · 2025Article
- Factors associated with unfavorable outcomes in older patients with traumatic brain injury: analysis from theFrontiers in neurology · 2024Article
- Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders.BMC neuroscience · 2023Review
- Influence of Genetic Variation inGenes · 2020Article
- Parental warmth interacts with several genes to affect executive function components: a genome-wide environment interaction study.BMC genetics · 2020Article
- Pharmacodynamic Gene Testing in Prader-Willi Syndrome.Frontiers in genetics · 2020Article
- Catechol-Frontiers in genetics · 2020Article
- Iowa Gambling Task and Distortion in Perception of Body Image Among Adolescent Women With Eating Disorders.Frontiers in psychology · 2020Article
- A Neurobehavioral Approach to Addiction: Implications for the Opioid Epidemic and the Psychology of Addiction.Psychological science in the public interest : a journal of the American Psychological Society · 2019Review
- The neuroanatomical basis of the Gambler's fallacy: A univariate and multivariate morphometric study.Human brain mapping · 2019Article
- The effect ofBrain and behavior · 2017Article
- Genetically-Driven Enhancement of Dopaminergic Transmission Affects Moral Acceptability in Females but Not in Males: A Pilot Study.Frontiers in behavioral neuroscience · 2017Article
- Epigenetic and Neural Circuitry Landscape of Psychotherapeutic Interventions.Psychiatry journal · 2017Review
- Adolescent behavioral and neural reward sensitivity: a test of the differential susceptibility theory.Translational psychiatry · 2016Article
- Anodal Stimulation of the Left DLPFC Increases IGT Scores and Decreases Delay Discounting Rate in Healthy Males.Frontiers in psychology · 2016Article
- Modeling neurodevelopmental cognitive deficits in tasks with cross-species translational validity.Genes, brain, and behavior · 2016Review
- Gray and white matter structures in the midcingulate cortex region contribute to body mass index in Chinese young adults.Brain structure & function · 2015Article
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12 authors.
Funding
Abstract
Both genetic and environmental factors have been shown to influence decision making, but their relative contributions and interactions are not well understood. The present study aimed to reveal possible gene-environment interactions on decision making in a large healthy sample. Specifically, we examined how the frequently studied COMT Val(158)Met polymorphism interacted with an environmental risk factor (i.e., stressful life events) and a protective factor (i.e., parental warmth) to influence affective decision making as measured by the Iowa Gambling Task. We found that stressful life events acted as a risk factor for poor IGT performance (i.e., high reward sensitivity) among Met carriers, whereas parental warmth acted as a protective factor for good IGT performance (i.e., higher IGT score) among Val/Val homozygotes. These results shed some new light on gene-environment interactions in decision making, which could potentially help us understand the underlying etiology of several psychiatric disorders associated with decision making impairment.
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