Evidence map›Paper›PMID 22997543›Full record

ReviewOxidative medicine and cellular longevity2012

Formation and regulation of adaptive response in nematode Caenorhabditis elegans.

Y-L Zhao, D-Y Wang

Abstract readReview
In one paragraph

Review in Oxidative medicine and cellular longevity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Temperature Effects on Expression Levels ofInternational journal of molecular sciences · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Why are nematodes so successful extremophiles?Communicative & integrative biology · 2021
    Article
  8. Enhanced Healthspan inFrontiers in pharmacology · 2021
    Article
  9. BioMed research international · 2020
    Article
  10. Adverse Effects of Hydroalcoholic Extracts and the Major Components in the Stems ofEvidence-based complementary and alternative medicine : eCAM · 2017
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Y-L ZhaoKey Laboratory of Environmental Medicine Engineering in Ministry of Education, Department of Biochemistry and Molecular Biology, Medical School of Southeast University, Nanjing 210009, China.
D-Y Wang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

All organisms respond to environmental stresses (e.g., heavy metal, heat, UV irradiation, hyperoxia, food limitation, etc.) with coordinated adjustments in order to deal with the consequences and/or injuries caused by the severe stress. The nematode Caenorhabditis elegans often exerts adaptive responses if preconditioned with low concentrations of agents or stressor. In C. elegans, three types of adaptive responses can be formed: hormesis, cross-adaptation, and dietary restriction. Several factors influence the formation of adaptive responses in nematodes, and some mechanisms can explain their response formation. In particular, antioxidation system, heat-shock proteins, metallothioneins, glutathione, signaling transduction, and metabolic signals may play important roles in regulating the formation of adaptive responses. In this paper, we summarize the published evidence demonstrating that several types of adaptive responses have converged in C. elegans and discussed some possible alternative theories explaining the adaptive response control.

Indexed as

Adaptation, PhysiologicalAnimalsAntioxidantsCaenorhabditis elegansCaenorhabditis elegans ProteinsEnvironmental PollutantsGlutathioneHeat-Shock ProteinsMetallothioneinOxidative StressRNA InterferenceSignal TransductionAntioxidantsCaenorhabditis elegans ProteinsEnvironmental PollutantsGlutathioneHeat-Shock ProteinsMetallothionein

Identifiers

PMID22997543
PMCPMC3446806

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.