ArticleAJR. American journal of roentgenology2012
CT grading of lung disease in lymphangioleiomyomatosis.
Article in AJR. American journal of roentgenology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Guideline
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- Automated Segmentation and Measurements of Pulmonary Cysts in Lymphangioleiomyomatosis across Multiple CT Scanner Platforms over a Period of Two Decades.Bioengineering (Basel, Switzerland) · 2023Article
- Computer grading of lung disease severity in patients with lymphangioleiomyomatosis referred for transplantation.BMC pulmonary medicine · 2022Article
- Lymphangioleiomyomatosis: a clinical review.Breathe (Sheffield, England) · 2020Review
- Effects of sirolimus in lymphangioleiomyomatosis patients on lung cysts and pulmonary function: long-term follow-up observational study.European radiology · 2020Observational
- Clinical CT underestimation of the percentage volume occupied by cysts in patients with lymphangioleiomyomatosis.Clinical imaging · 2020Article
- Use of CT Imaging to Quantify Progression and Response to Treatment in Lymphangioleiomyomatosis.Chest · 2019Article
- Optimization of a secondary VOI protocol for lung imaging in a clinical CT scanner.Journal of applied clinical medical physics · 2018Article
- Immunohistological features related to functional impairment in lymphangioleiomyomatosis.Respiratory research · 2018Article
- Rates of change in FEVThe European respiratory journal · 2018Article
- Article
- Lung densitometry: why, how and when.Journal of thoracic disease · 2017Review
- EPIDEMIOLOGY, PATHOGENESIS and DIAGNOSIS of LYMPHANGIOLEIOMYOMATOSIS.Expert opinion on orphan drugs · 2016Article
- Severity and outcome of cystic lung disease in women with tuberous sclerosis complex.The European respiratory journal · 2015Article
- Clinical features, epidemiology, and therapy of lymphangioleiomyomatosis.Clinical epidemiology · 2015Review
- Article
- Sustained effects of sirolimus on lung function and cystic lung lesions in lymphangioleiomyomatosis.American journal of respiratory and critical care medicine · 2014Article
- Towards personalised therapy for lymphangioleiomyomatosis: lessons from cancer.European respiratory review : an official journal of the European Respiratory Society · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe aim of this study was to determine whether a CT-based method shows lung lesions, grades disease severity, and evaluates lung tissue in areas adjacent to or remote from cysts in patients with lymphangioleiomyomatosis (LAM), a cystic lung disease that may cause respiratory failure and death. MATERIALS AND
methodsThree hundred twenty-six CT examinations of 52 patients with LAM were studied. After the lungs had been divided into segments and images had been subdivided into texture blocks, a multidimensional feature vector was used to differentiate and group each texture block. Cysts were outlined, and texture around and away from cysts was analyzed. Sequential CT scans and pulmonary function test results were evaluated to assess the trend of change. Histopathologic examinations were performed of biopsy specimens from 45 patients.
resultsDifferences in texture features between areas adjacent to and areas remote from the cysts were observed. The cyst score and sum entropy in areas around the cysts correlated with lung function (p<0.0001). Emphysematouslike changes in noncystic areas were identified in lung tissue of 31 of 45 patients.
conclusionA computational method that uses texture analysis and feature correlation can identify and quantify cystic areas where LAM exists and can detect abnormalities in areas near cysts. Pathologic data also show lung damage in areas adjacent to cysts. Several texture features correlate with lung function. Declines in lung function paralleled changes in texture features. In LAM, cystic changes alone may not define the extent of lung destruction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.