ArticleCerebral cortex (New York, N.Y. : 1991)2014
Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Neurocognitive and neurobiological effects of low dose organophosphate exposure.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Selective modulation of epileptic tissue by an adenosine ABritish journal of pharmacology · 2024Article
- Adenosine ABiomolecules · 2023Article
- A maestro role of adenosine APurinergic signalling · 2022Article
- Discovery of Highly Potent Adenosine AACS chemical neuroscience · 2021Article
- Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum.Nature communications · 2021Article
- Seasonal changes in adenosine kinase in tanycytes of the Arctic ground squirrel (Urocitellus parryii).Journal of chemical neuroanatomy · 2021Article
- The Role of Cerebral Metabolism in Improving Time Pressured Decisions.Frontiers in psychology · 2021Article
- The Purine Salvage Pathway and the Restoration of Cerebral ATP: Implications for Brain Slice Physiology and Brain Injury.Neurochemical research · 2019Review
- Dynamic Changes of Astrocytes and Adenosine Signaling in Rat Hippocampus in Post-status Epilepticus Model of Epileptogenesis.Cellular and molecular neurobiology · 2018Article
- Article
- Regional Variations of Spontaneous, Transient Adenosine Release in Brain Slices.ACS chemical neuroscience · 2018Article
- Connexins and pannexins: At the junction of neuro-glial homeostasis & disease.Journal of neuroscience research · 2018Review
- Adenosine A2A receptors in neuronal outgrowth: a target for nerve regeneration?Neural regeneration research · 2016Article
- Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation.Frontiers in molecular neuroscience · 2016Article
- Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction.Frontiers in molecular neuroscience · 2016Article
- From unwitnessed fatality to witnessed rescue: Pharmacologic intervention in sudden unexpected death in epilepsy.Epilepsia · 2016Review
- Comorbidities in Neurology: Is adenosine the common link?Neuropharmacology · 2015Review
- Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.Epilepsia · 2015Article
- Cell type-specific effects of adenosine on cortical neurons.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 6 countries.
Funding
Abstract
Extracellular adenosine, a key regulator of neuronal excitability, is metabolized by astrocyte-based enzyme adenosine kinase (ADK). We hypothesized that ADK might be an upstream regulator of adenosine-based homeostatic brain functions by simultaneously affecting several downstream pathways. We therefore studied the relationship between ADK expression, levels of extracellular adenosine, synaptic transmission, intrinsic excitability, and brain-derived neurotrophic factor (BDNF)-dependent synaptic actions in transgenic mice underexpressing or overexpressing ADK. We demonstrate that ADK: 1) Critically influences the basal tone of adenosine, evaluated by microelectrode adenosine biosensors, and its release following stimulation; 2) determines the degree of tonic adenosine-dependent synaptic inhibition, which correlates with differential plasticity at hippocampal synapses with low release probability; 3) modulates the age-dependent effects of BDNF on hippocampal synaptic transmission, an action dependent upon co-activation of adenosine A2A receptors; and 4) influences GABAA receptor-mediated currents in CA3 pyramidal neurons. We conclude that ADK provides important upstream regulation of adenosine-based homeostatic function of the brain and that this mechanism is necessary and permissive to synaptic actions of adenosine acting on multiple pathways. These mechanistic studies support previous therapeutic studies and implicate ADK as a promising therapeutic target for upstream control of multiple neuronal signaling pathways crucial for a variety of neurological disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.