ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012
Accuracy of low-dose rubidium-82 myocardial perfusion imaging for detection of coronary artery disease using 3D PET and normal database interpretation.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01128023 (Rubidium-82 - An Alternative Radiopharmaceutical for Myocardial Imaging), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Rubidium-82 - An Alternative Radiopharmaceutical for Myocardial Imaging(Rb-ARMI)
Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Consistent tracer administration profile improves test-retest repeatability of myocardial blood flow quantification withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Trial
- The role of nuclear imaging in detection of coronary artery disease: a comprehensive review.American journal of translational research · 2026Review
- Exponential dosing to standardize myocardial perfusion image quality with rubidium-82 PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Quantification of myocardial blood flow (MBF) and reserve (MFR) incorporated with a novel segmentation approach: Assessments of quantitative precision and the lower limit of normal MBF and MFR in patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- PET/CT Myocardial Perfusion Imaging Acquisition and Processing: Ten Tips and Tricks to Help You Succeed.Current cardiology reports · 2021Review
- PET-Based Imaging of Ischemic Heart Disease.PET clinics · 2019Review
- Clinical performance of Rb-82 myocardial perfusion PET and Tc-99m-based SPECT in patients with extreme obesity.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Implementation of a cardiac PET stress program: comparison of outcomes to the preceding SPECT era.JCI insight · 2018Observational
- PET should replace SPECT in cardiac imaging for diagnosis and risk assessment of patients with known or suspected CAD: Pro.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Status of cardiovascular PET radiation exposure and strategies for reduction: An Information Statement from the Cardiovascular PET Task Force.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Single low-dose CT scan optimized for rest-stress PET attenuation correction and quantification of coronary artery calcium.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Noninvasive imaging in coronary artery disease.Seminars in nuclear medicine · 2014Review
- The role of PET quantification in cardiovascular imaging.Clinical and translational imaging · 2014Article
- CFR and FFR assessment with PET and CTA: strengths and limitations.Current cardiology reports · 2014Review
- Characterizing the normal range of myocardial blood flow with ⁸²rubidium and ¹³N-ammonia PET imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Myocardial perfusion imaging with PET.Imaging in medicine · 2013Article
- Low-dose 3D (82)Rb PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOur aim was to develop a normal database to be used for quantification of myocardial perfusion and diagnosis of "obstructive coronary artery disease" (CAD) using low-dose rubidium-82 three-dimensional (3D) positron emission tomography (PET)-CT.
methodsFrom a record of 1,501 patients, 77 were identified as having low-likelihood (LLK) of CAD. Forty LLK patients were used to construct a normal database using 4DM-PET, the remainder used for validation of normalcy. A group of 70 patients with CAD who had invasive coronary angiography and PET-CT were used to evaluate the accuracy of the database for detecting CAD using the sum-stress-score. The effect of clinical exclusion criteria and the inclusion of LLK patients were evaluated.
resultsThe normal database for CAD detection had a normalcy rate of 95%. Sensitivity was 100% for detecting patients with either 50% or 70% stenosis. Optimal specificity was 87% for either 50% or 70% stenosis. For localizing disease at 50% stenosis in the left anterior descending, left circumflex, and right coronary artery, sensitivity ranged from 59% to 68%, while specificity was maintained at 87-89%. Similarly, at 70% stenosis, sensitivity ranged from 64% to 79%, and specificity from 87% to 91%.
conclusionsA normal database containing the relative perfusion scores of patients with LLK of CAD can be used to accurately diagnose obstructive coronary disease using low-dose Rb-82 with 3D PET-CT imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.