ArticleHuman brain mapping2014
Regional specificity of sex effects on subcortical volumes across the lifespan in healthy aging.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of sex differences in human brain structure.Neuroscience and biobehavioral reviews · 2014Pooled it
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- Different Regional Patterns in Gray Matter-based Age Prediction.Neuroscience bulletin · 2023Article
- Thalamic nuclei atrophy at high and heterogenous rates during cognitively unimpaired human aging.NeuroImage · 2022Article
- Exploring the association between social behaviour, trust, and its neural correlates in first episode psychosis patients and in individuals at clinical high risk for psychosis.The British journal of clinical psychology · 2022Article
- Reexperiencing and anxious arousal symptoms in relation to volumes of thalamus nuclei in posttraumatic stress spectrum adults.Brain and behavior · 2022Article
- Novel characterization of the relationship between verbal list-learning outcomes and hippocampal subfields in healthy adults.Human brain mapping · 2021Article
- Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders.Human brain mapping · 2021Article
- Sex as a Risk Factor for Developing Cognitive Impairments in National Alzheimer's Coordinating Center Participants.Journal of Alzheimer's disease reports · 2021Article
- Sex-Based Differences in Cortical and Subcortical Development in 436 Individuals Aged 4-54 Years.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Amygdala subnuclei and healthy cognitive aging.Human brain mapping · 2019Article
- Effects of Age and Sex on Subcortical Volumes.Frontiers in aging neuroscience · 2019Article
- Social Mindfulness and Psychosis: Neural Response to Socially Mindful Behavior in First-Episode Psychosis and Patients at Clinical High-Risk.Frontiers in human neuroscience · 2019Article
- Associations between adolescent cannabis use and brain structure in psychosis.Psychiatry research. Neuroimaging · 2018Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When conceptualizing age-specific onsets and sex-specific characteristics of neuropsychiatric diseases in a neurobiological context, it may be crucially important to consider differential trajectories of aging. Here, we investigated effects of age, sex, and their interactions on absolute and relative volumes of subcortical structures with known involvement in psychiatric disorders, including the basal ganglia, thalamus, hippocampus, and amygdala. Structural MRI data of 76 healthy subjects (38 males, 19-70 years) from the ICBM database were analyzed. Age-related absolute atrophy was generally found in the basal ganglia and thalamus, while in the hippocampus decline was only observed in males, and was generally absent in the amygdala. Disproportionate degeneration in the basal ganglia and thalamus, exceeding cortical decline was specific for females. When allowing higher-order models, a quadratic model could better describe the negative relation of absolute volume and age in the basal ganglia in males, and generally in the hippocampus and amygdala. We could show that negative age-relations are highly specific for certain subcortical structures in either gender. Importantly these findings also emphasize the significant impact of analytical strategies when deciding for correction of subcortical volumes to the whole-brain decline. Specifically, in the basal ganglia disproportionate shrinkage in females was suggested by the relative analysis while absolute volume analysis rather stressed an accelerating decline in older males. Given strong involvement of the basal ganglia in both cognitive aging and emotional regulation, our findings may be crucial for studies investigating the onset and prevalence of dementia and depressive symptoms in male and female aging.
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