ArticleRadiology2012
Hyperpolarized water as an MR imaging contrast agent: feasibility of in vivo imaging in a rat model.
Article in Radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- On the effects of hyperpolarized water-based dissolution on the solute and solventPhysical chemistry chemical physics : PCCP · 2026Article
- Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI.Journal of magnetic resonance imaging : JMRI · 2026Review
- Multidimensional pH-Temperature Mapping of SABRE-SHEATHThe journal of physical chemistry. B · 2025Article
- Hyperpolarized Water for Coronary Artery Angiography and Whole-Heart Myocardial Perfusion Quantification.Tomography (Ann Arbor, Mich.) · 2024Article
- Challenges and Advances in the Application of Dynamic Nuclear Polarization to Liquid-State NMR Spectroscopy.The journal of physical chemistry. B · 2021Review
- High-sensitivity in vivo contrast for ultra-low field magnetic resonance imaging using superparamagnetic iron oxide nanoparticles.Science advances · 2020Article
- Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals.Communications chemistry · 2020Article
- Increased flow rate of hyperpolarized aqueous solution for dynamic nuclear polarization-enhanced magnetic resonance imaging achieved by an open Fabry-Pérot type microwave resonator.Magnetic resonance (Gottingen, Germany) · 2020Article
- Biochemical phosphates observed using hyperpolarizedNature communications · 2017Article
- Nanodiamond-enhanced MRI via in situ hyperpolarization.Nature communications · 2017Article
- The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging.Advanced drug delivery reviews · 2017Review
- Continuous-flow DNP polarizer for MRI applications at 1.5 T.Scientific reports · 2017Article
- A New Ir-NHC Catalyst for Signal Amplification by Reversible Exchange in D2 O.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Optimization and prediction of the electron-nuclear dipolar and scalar interaction inChemical science · 2015Article
- Nanoscale Catalysts for NMR Signal Enhancement by Reversible Exchange.The journal of physical chemistry. C, Nanomaterials and interfaces · 2015Article
- NMR hyperpolarization techniques for biomedicine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- Heterogeneous solution NMR signal amplification by reversible exchange.Angewandte Chemie (International ed. in English) · 2014Article
- Quantitative cw Overhauser effect dynamic nuclear polarization for the analysis of local water dynamics.Progress in nuclear magnetic resonance spectroscopy · 2013Review
- Overhauser Dynamic Nuclear Polarization-Enhanced NMR Relaxometry.Microporous and mesoporous materials : the official journal of the International Zeolite Association · 2013Article
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8 authors.
Funding
Abstract
purposeTo assess the feasibility of a perfusion magnetic resonance (MR) imaging technique that uses Overhauser dynamic nuclear polarization (DNP) to provide contrast during the continuous delivery of hyperpolarized water in rats. MATERIALS AND
methodsProtocols approved by the local institutional animal care and use committees were followed. Twelve male Wistar rats were anesthetized and prepared by placing injection tubing in the subcutaneous layer (n=3), peritoneum (n=3), aorta (n=3), or carotid artery (n=3). Water was hyperpolarized by means of Overhauser DNP in the 0.35-T fringe field of a 1.5-T MR imaging magnet by using a custom-built system to continuously deliver radical-free hyperpolarized water to the subject. Fast gradient-echo and spoiled gradient-recalled-echo MR imaging sequences were used. The signal-to-noise ratio (SNR) of the images was calculated and compared.
resultsImages showed greatly altered SNR and enhanced flow contrast at all injection locations. For subcutaneous and intraperitoneal injections, the water perfusion trajectory was observed for approximately 5 seconds after injection. Flow through a 4.2-cm length of artery was seen during intra-aortic injection. The right hemisphere of the brain was seen during injection into the right carotid artery. Images with hyperpolarized water had greatly altered SNR compared with images without injection or with the injection of nonhyperpolarized water, with a range of 13%-27% for the carotid and 444%-2900% for the other regions.
conclusionPerfusion contrast for MR imaging can be obtained by continuously infusing hyperpolarized water, providing localized angiography or brain perfusion information in vivo for rat models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.