Evidence map›Paper›PMID 22996743›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013

Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial.

K M Winters-Stone, J Dobek, L M Nail, J A Bennett, M C Leo, B Torgrimson-Ojerio, S-W Luoh, A Schwartz

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00659906 (Optimizing Body Composition & Health After Breast Cancer), which is not on this map. Cited by 58 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 15 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00659906 nacompletednot on this map

Optimizing Body Composition & Health After Breast Cancer

TypeinterventionalSponsorOHSU Knight Cancer InstituteRan2006 to 2009Enrolled71ConditionsBreast Neoplasm, Osteoporosis, PostmenopausalArmsResistance Exercise, Flexibility Training
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 15 syntheses or guidelines pooled it, 132 citations in OpenAlex.

  1. Pooled it
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  5. The effects of exercise on the bone health of people with cancer: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Pooled it
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  7. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
    Pooled it
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  10. The effect of exercise on bone mineral density in adult cancer survivors: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Pooled it
  11. Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018
    Pooled it
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  14. The effects of resistance exercise on physical performance and health-related quality of life in prostate cancer patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015
    Pooled it
  15. The effect of physical exercise on bone density in middle-aged and older men: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

K M Winters-StoneSchool of Nursing, Oregon Health & Science University, Portland, OR, USA. wintersk@ohsu.edu
J Dobek
L M Nail
J A Bennett
M C Leo
B Torgrimson-Ojerio
S-W Luoh
A Schwartz
Oregon Health & Science University · USIdaho State University · USKaiser Permanente Center for Health Research · USPortland VA Medical Center · US

Funding

Comparison of Aerobic and Resistance Exercise in Older Breast Cancer SurvivorsR01CA120123 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI WINTERS-STONE, KERRI M · 2007 to 2009
$849k
NCI NIH HHS R01 CA120123
6 · The paper itself

Abstract

unlabelledOur randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year.

introductionCancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause.

methodsWe conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter).

resultsThere were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck-POWIR, 0.004 ± 0.093 g/cm(2) vs. FLEX, -0.010 ± 0.089 g/cm(2); p < 0.01; spine-POWIR, -0.003 ± 0.114 g/cm(2) vs. FLEX, -0.020 ± 0.110 g/cm(2); p = 0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; p < 0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (p < 0.03).

conclusionImpact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.

Indexed as

AdultAntineoplastic AgentsBody CompositionBone DensityBreast NeoplasmsExercise TherapyFemaleFemur NeckHumansLumbar VertebraeMenopause, PrematureMiddle AgedOsteoporosis, PostmenopausalPatient ComplianceResistance TrainingSurvivorsAntineoplastic Agents

Identifiers

PMID22996743
PMCPMC3856427
OpenAlexW2006217454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.