ArticleBMJ quality & safety2013
'Matching Michigan': a 2-year stepped interventional programme to minimise central venous catheter-blood stream infections in intensive care units in England.
Article in BMJ quality & safety, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 4 of them syntheses that pooled it.
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Who cites it
96 citing papers in PubMed, 4 syntheses or guidelines pooled it, 298 citations in OpenAlex.
- Optimising paediatric afferent component early warning systems: a hermeneutic systematic literature review and model development.BMJ open · 2019Pooled it
- Association of Anaesthetists of Great Britain and Ireland: Safe vascular access 2016.Anaesthesia · 2016Guideline
- What are effective strategies for the implementation of care bundles on ICUs: a systematic review.Implementation science : IS · 2015Pooled it
- epic3: national evidence-based guidelines for preventing healthcare-associated infections in NHS hospitals in England.The Journal of hospital infection · 2014Guideline
- Accuracy and usability of a diagnostic decision support system in the diagnosis of three representative rheumatic diseases: a randomized controlled trial among medical students.Arthritis research & therapy · 2021Trial
- Chlorhexidine gluconate transparent dressing does not decrease central line-associated bloodstream infection in critically ill patients: A randomized controlled trial.International journal of nursing practice · 2019Trial
- Effect of a scaled-up neonatal resuscitation quality improvement package on intrapartum-related mortality in Nepal: A stepped-wedge cluster randomized controlled trial.PLoS medicine · 2019Trial
- Prevention of hospital infections by intervention and training (PROHIBIT): results of a pan-European cluster-randomized multicentre study to reduce central venous catheter-related bloodstream infections.Intensive care medicine · 2018Trial
- A comprehension scale for central-line associated bloodstream infection: Results of a preliminary survey and factor analysis.PloS one · 2018Trial
- The Effect of a Freely Available Flipped Classroom Course on Health Care Worker Patient Safety Culture: A Prospective Controlled Study.Journal of medical Internet research · 2016Trial
- The Generativity of Variability for Evidence-Based Practice.Nursing philosophy : an international journal for healthcare professionals · 2026Article
- Practice guideline on the prevention and treatment of central line-associated bloodstream infection: Part 2 - Treatment.Journal of intensive medicine · 2026Article
- Scaling up improvement: the drive to reduce healthcare-associated infections in public Brazilian intensive care units across all patient ages.Infection control and hospital epidemiology · 2026Article
- Predictive factors for prolonged nutritional support after oesophagogastric cancer resection.Annals of the Royal College of Surgeons of England · 2026Article
- Ethical considerations in quality improvement.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Using perioperative patient safety guidelines to drive systems change.British journal of anaesthesia · 2025Article
- Integrated Multimodal Strategy to Reduce Healthcare-Associated Infections in a Trauma ICU: Impact of a Quality Improvement Project.Journal of clinical medicine · 2025Article
- The National Paediatric Applied Research Translation Initiative (N-PARTI): using implementation science to improve primary care for Australian children with asthma, type 1 diabetes, and infections.BMC health services research · 2025Article
- Bloodstream Infections in Critical Care Units in England, April 2017 to March 2023: Results from the First Six Years of a National Surveillance Programme.Microorganisms · 2025Article
- Quality and reporting of large-scale improvement programmes: a review of maternity initiatives in the English NHS, 2010-2023.BMJ quality & safety · 2024Review
36 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBloodstream infections from central venous catheters (CVC-BSIs) increase morbidity and costs in intensive care units (ICUs). Substantial reductions in CVC-BSI rates have been reported using a combination of technical and non-technical interventions.
methodsWe conducted a 2-year, four-cluster, stepped non-randomised study of technical and non-technical (behavioural) interventions to prevent CVC-BSIs in adult and paediatric ICUs in England. Random-effects Poisson regression modelling was used to compare infection rates. A sample of ICUs participated in data verification.
resultsOf 223 ICUs in England, 215 (196 adult, 19 paediatric) submitted data on 2479 of 2787 possible months and 147 (66%) provided complete data. The exposure rate was 438 887 (404 252 adult and 34 635 paediatric) CVC-patient days. Over 20 months, 1092 CVC-BSIs were reported. Of these, 884 (81%) were ICU acquired. For adult ICUs, the mean CVC-BSI rate decreased over 20 months from 3.7 in the first cluster to 1.48 CVC-BSIs/1000 CVC-patient days (p<0.0001) for all clusters combined, and for paediatric ICUs from 5.65 to 2.89 (p=0.625). The trend for infection rate reduction did not accelerate following interventions training. CVC utilisation rates remained stable. Pre-ICU infections declined in parallel with ICU-acquired infections. Criterion-referenced case note review showed high agreement between adjudicators (κ 0.706) but wide variation in blood culture sampling rates and CVC utilisation. Generic infection control practices varied widely.
conclusionsThe marked reduction in CVC-BSI rates in English ICUs found in this study is likely part of a wider secular trend for a system-wide improvement in healthcare-associated infections. Opportunities exist for greater harmonisation of infection control practices. Future studies should investigate causal mechanisms and contextual factors influencing the impact of interventions directed at improving patient care.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.