ArticlePharmaceutical research2013
Exploring the solid-form landscape of pharmaceutical hydrates: transformation pathways of the sodium naproxen anhydrate-hydrate system.
Article in Pharmaceutical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- Application of TGA/c-DTA for Distinguishing between Two Forms of Naproxen in Pharmaceutical Preparations.Pharmaceutics · 2023Article
- Pre-clinical Formulation Development of an in situ Meglumine Salt of AZD5991: A Novel Macrocyclic Mcl-1 Inhibitor.Pharmaceutical research · 2023Article
- Pharmaceutical Hydrates Analysis-Overview of Methods and Recent Advances.Pharmaceutics · 2020Review
- The Eight Hydrates of Strychnine Sulfate.Crystal growth & design · 2020Article
- Machine-Vision-Enabled Salt Dissolution Analysis.Analytical chemistry · 2020Article
- Experimental and Computational Hydrate Screening: Cytosine, 5-Flucytosine and Their Solid Solution.Crystal growth & design · 2017Article
- Stoichiometric and Non-Stoichiometric Hydrates of Brucine.Crystal growth & design · 2016Article
- 4-Aminoquinaldine monohydrate polymorphism: Prediction and impurity aided discovery of a difficult to access stable form.CrystEngComm · 2016Article
- Computational and Experimental Characterization of Five Crystal Forms of Thymine: Packing Polymorphism, Polytypism/Disorder and Stoichiometric 0.8-Hydrate.Crystal growth & design · 2016Article
- Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storage.Molecules (Basel, Switzerland) · 2016Article
- Structural Properties, Order-Disorder Phenomena, and Phase Stability of Orotic Acid Crystal Forms.Molecular pharmaceutics · 2016Article
- Navigating the Waters of Unconventional Crystalline Hydrates.Molecular pharmaceutics · 2015Article
- Insights into hydrate formation and stability of morphinanes from a combination of experimental and computational approaches.Molecular pharmaceutics · 2014Article
- Structural basis for the transformation pathways of the sodium naproxen anhydrate-hydrate system.IUCrJ · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo understand the transformation pathways amongst anhydrate/hydrate solid forms of sodium naproxen and to highlight the importance of a polymorphic dihydrate within this context.
methodsMulti-temperature dynamic vapour sorption (DVS) analysis combined with variable-humidity X-ray powder diffraction (XRPD) to establish the transformation pathways as a function of temperature and humidity. XRPD and thermogravimetric analysis (TGA) to characterise bulk samples. Monitoring of in-situ dehydration using solid-state (13)C CP/MAS spectroscopy.
resultsAt 25 °C, anhydrous sodium naproxen (AH) transforms directly to one dihydrate polymorph (DH-II). At 50 °C, AH transforms stepwise to a monohydrate (MH) then to the other dihydrate polymorph (DH-I). DH-II transforms to a tetrahydrate (TH) more readily than DH-I transforms to TH. Both dihydrate polymorphs transform to the same MH.
conclusionsThe properties of the polymorphic dihydrate control the transformation pathways of sodium naproxen.
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