ArticleMuscle & nerve2012
Corneal confocal microscopy detects small-fiber neuropathy in Charcot-Marie-Tooth disease type 1A patients.
Article in Muscle & nerve, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 106 citations in OpenAlex.
- Distinct small-fiber dysfunction profiles in CMT1A and RFC1 disease: a multimodal study.Journal of neurology · 2026Article
- Evaluation of corneal subbasal nerve plexus as a predictor of radiosurgery outcome in trigeminal neuralgia.Neurosurgical review · 2026Article
- Corneal confocal microscopy in fibromyalgia syndrome: small fiber neuropathy, and treatment outcomes.Eye (London, England) · 2026Article
- The intrinsic reason why complementary tests (clinical neurophysiology, neuroimaging, skin biopsy) cannot establish the diagnosis of neuropathic pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Global hotspots and trends in diabetic peripheral neuropathy research from 2011 to 2023.Medicine · 2024Article
- Retinal nerve fibre layer thinning and corneal nerve loss in patients with Bardet-Biedl syndrome.BMC medical genomics · 2023Article
- Severe Dry Eye Disease in Charcot-Marie-Tooth Disease: A Comprehensive Case Report.The American journal of case reports · 2023Article
- Corneal nerve fiber involvement in chronic inflammatory demyelinating polyneuropathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Corneal confocal microscopy identifies corneal nerve loss and increased Langerhans cells in presymptomatic carriers and patients with hereditary transthyretin amyloidosis.Journal of neurology · 2023Article
- Corneal Sub-Basal Nerve Plexus in Non-Diabetic Small Fiber Polyneuropathies and the Diagnostic Role of In Vivo Corneal Confocal Microscopy.Journal of clinical medicine · 2023Review
- Artificial Intelligence and Corneal Confocal Microscopy: The Start of a Beautiful Relationship.Journal of clinical medicine · 2022Review
- Charcot-Marie-Tooth Disease and Implications on Corneal Refractive Surgery.Ophthalmology and therapy · 2022Article
- Corneal confocal microscopy to detect early immune-mediated small nerve fibre loss in AL amyloidosis.Annals of clinical and translational neurology · 2022Article
- Using Corneal Confocal Microscopy to Identify Therapeutic Agents for Diabetic Neuropathy.Journal of clinical medicine · 2022Article
- Corneal Confocal Microscopy and the Nervous System: Introduction to the Special Issue.Journal of clinical medicine · 2022Article
- Corneal Confocal Microscopy Findings in Neuro Lyme Disease: A Case Report.Diagnostics (Basel, Switzerland) · 2022Article
- Implementation of corneal confocal microscopy for screening and early detection of diabetic neuropathy in primary care alongside retinopathy screening: Results from a feasibility study.Frontiers in endocrinology · 2022Article
- Comparing the results of manual and automated quantitative corneal neuroanalysing modules for beginners.Scientific reports · 2021Article
- Left to themselves: Time to target chronic pain in childhood rare diseases.Neuroscience and biobehavioral reviews · 2021Review
- Ocular Involvement in Hereditary Amyloidosis.Genes · 2021Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
introductionAlthough unmyelinated nerve fibers are affected in Charcot-Marie-Tooth type 1A (CMT1A) disease, they have not been studied in detail due to the invasive nature of the techniques needed to study them. We established alterations in C-fiber bundles of the cornea in patients with CMT1A using non-invasive corneal confocal microscopy (CCM).
methodsTwelve patients with CMT1A and 12 healthy control subjects underwent assessment of neuropathic symptoms and deficits, electrophysiology, quantitative sensory testing, corneal sensitivity, and corneal confocal microscopy.
resultsCorneal sensitivity, corneal nerve fiber density, corneal nerve branch density, corneal nerve fiber length, and corneal nerve fiber tortuosity were significantly reduced in CMT1A patients compared with controls. There was a significant correlation between corneal sensation and CCM parameters with the severity of painful neuropathic symptoms, cold and warm thresholds, and median nerve CMAP amplitude.
conclusionsCCM demonstrates significant damage to C-fiber bundles, which relates to some measures of neuropathy in CMT1A patients.
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Registered trials
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