ArticlePhysics in medicine and biology2012
Improving quantification of intravascular fluorescence imaging using structural information.
Article in Physics in medicine and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Accounting for blood attenuation in intravascular near-infrared fluorescence-ultrasound imaging using a fluorophore-coated guidewire.Journal of biomedical optics · 2023Article
- A Dual-Modality Hybrid Imaging System Harnesses Radioluminescence and Sound to Reveal Molecular Pathology of Atherosclerotic Plaques.Scientific reports · 2018Article
- Quantitative intravascular biological fluorescence-ultrasound imaging of coronary and peripheral arteries in vivo.European heart journal. Cardiovascular Imaging · 2017Article
- Everolimus-eluting stents stabilize plaque inflammation in vivo: assessment by intravascular fluorescence molecular imaging.European heart journal. Cardiovascular Imaging · 2017Article
- Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy.International journal of molecular sciences · 2016Article
- Fluorescence lifetime imaging and intravascular ultrasound: co-registration study using ex vivo human coronaries.IEEE transactions on medical imaging · 2015Article
- Rotational multispectral fluorescence lifetime imaging and intravascular ultrasound: bimodal system for intravascular applications.Journal of biomedical optics · 2014Article
- Fiber-optic system for dual-modality imaging of glucose probes 18F-FDG and 6-NBDG in atherosclerotic plaques.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Intravascular near-infrared fluorescence (iNIRF) imaging can enable the in vivo visualization of biomarkers of vascular pathology, including high-risk plaques. The technique resolves the bio-distribution of systemically administered fluorescent probes with molecular specificity in the vessel wall. However, the geometrical variations that may occur in the distance between fibre-tip and vessel wall can lead to signal intensity variations and challenge quantification. Herein we examined whether the use of anatomical information of the cross-section vessel morphology, obtained from co-registered intravascular ultrasound (IVUS), can lead to quantification improvements when fibre-tip and vessel wall distance variations are present. The algorithm developed employs a photon propagation model derived from phantom experiments that is used to calculate the relative attenuation of fluorescence signals as they are collected over 360° along the vessel wall, and utilizes it to restore accurate fluorescence readings. The findings herein point to quantification improvements when employing hybrid iNIRF, with possible implications to the clinical detection of high-risk plaques or blood vessel theranostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.