ArticleBiophysical journal2012
Computational modeling of single-cell migration: the leading role of extracellular matrix fibers.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 114 citations in OpenAlex.
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- A Simple Framework for Agent-Based Modeling with Extracellular Matrix.Bulletin of mathematical biology · 2025Article
- Modelling the Impact of HIF on Metabolism and the Extracellular Matrix: Consequences for Tumour Growth and Invasion.Bulletin of mathematical biology · 2025Article
- Understanding the interplay between extracellular matrix topology and tumor-immune interactions: Challenges and opportunities.Oncotarget · 2024Review
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- Dynamics of Fibril Collagen Remodeling by Tumor Cells: A Model of Tumor-Associated Collagen Signatures.Cells · 2023Article
- Deformability and collision-induced reorientation enhance cell topotaxis in dense microenvironments.Biophysical journal · 2023Article
- Hybrid cellular Potts and bead-spring modeling of cells in fibrous extracellular matrix.Biophysical journal · 2023Article
- Cell Dissemination in Pancreatic Cancer.Cells · 2022Review
- Elucidating the signal for contact guidance contained in aligned fibrils with a microstructural-mechanical model.Journal of the Royal Society, Interface · 2022Article
- Multi-Cue Kinetic Model with Non-Local Sensing for Cell Migration on a Fiber Network with Chemotaxis.Bulletin of mathematical biology · 2022Article
- Advances in non-invasive biosensing measures to monitor wound healing progression.Frontiers in bioengineering and biotechnology · 2022Review
- Adhesion strength and contractility enable metastatic cells to become adurotactic.Cell reports · 2021Article
- Bridging from single to collective cell migration: A review of models and links to experiments.PLoS computational biology · 2020Review
- Computational models of migration modes improve our understanding of metastasis.APL bioengineering · 2020Review
- The Impact of Elastic Deformations of the Extracellular Matrix on Cell Migration.Bulletin of mathematical biology · 2020Article
- Exogenous diethyl aminoethyl hexanoate ameliorates low temperature stress by improving nitrogen metabolism in maize seedlings.PloS one · 2020Article
- A mechanical toy model linking cell-substrate adhesion to multiple cellular migratory responses.Journal of biological physics · 2019Article
- Are the Effects of Independent Biophysical Factors Linearly Additive? A 3D Tumor Migration Model.Biophysical journal · 2019Article
- Mechanochemical Coupling and Junctional Forces during Collective Cell Migration.Biophysical journal · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Cell migration is vitally important in a wide variety of biological contexts ranging from embryonic development and wound healing to malignant diseases such as cancer. It is a very complex process that is controlled by intracellular signaling pathways as well as the cell's microenvironment. Due to its importance and complexity, it has been studied for many years in the biomedical sciences, and in the last 30 years it also received an increasing amount of interest from theoretical scientists and mathematical modelers. Here we propose a force-based, individual-based modeling framework that links single-cell migration with matrix fibers and cell-matrix interactions through contact guidance and matrix remodelling. With this approach, we can highlight the effect of the cell's environment on its migration. We investigate the influence of matrix stiffness, matrix architecture, and cell speed on migration using quantitative measures that allow us to compare the results to experiments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.