ArticleBiophysical journal2012
Effect of chain chirality on the self-assembly of sickle hemoglobin.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Dynamics of deformable straight and curved prolate capsules in simple shear flow.Physical review fluids · 2019Article
- Molecular insights into the irreversible mechanical behavior of sickle hemoglobin.Journal of biomolecular structure & dynamics · 2019Article
- Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells.Biosensors · 2018Review
- Local Hematocrit Fluctuation Induced by Malaria-Infected Red Blood Cells and Its Effect on Microflow.BioMed research international · 2018Article
- Mesoscopic Adaptive Resolution Scheme toward Understanding of Interactions between Sickle Cell Fibers.Biophysical journal · 2017Article
- Patient-specific modeling of individual sickle cell behavior under transient hypoxia.PLoS computational biology · 2017Article
- Computational Biomechanics of Human Red Blood Cells in Hematological Disorders.Journal of biomechanical engineering · 2017Review
- Biomechanics and biorheology of red blood cells in sickle cell anemia.Journal of biomechanics · 2017Review
- MD/DPD Multiscale Framework for Predicting Morphology and Stresses of Red Blood Cells in Health and Disease.PLoS computational biology · 2016Article
- Dynamic and rheological properties of soft biological cell suspensions.Rheologica acta · 2016Article
- Probing the Twisted Structure of Sickle Hemoglobin Fibers via Particle Simulations.Biophysical journal · 2016Article
- Patient-specific blood rheology in sickle-cell anaemia.Interface focus · 2016Article
- Transport dissipative particle dynamics model for mesoscopic advection-diffusion-reaction problems.The Journal of chemical physics · 2015Article
- Large-scale dissipative particle dynamics simulations of self-assembled amphiphilic systems.Chemical communications (Cambridge, England) · 2014Article
- Continuum- and particle-based modeling of shapes and dynamics of red blood cells in health and disease.Soft matter · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
We present simulation results on the self-assembly behavior of sickle hemoglobin (HbS). A coarse-grained HbS model, which contains hydrophilic and hydrophobic particles explicitly, is constructed to match the structural properties and physical description of HbS. The hydrophobic interactions are shown to be necessary with chirality being the main driver for the formation of HbS fibers. In the absence of chain chirality, only small self-assembled aggregates are observed whereas self-assembled elongated steplike bundle microstructures appear when we include chain chirality. We also investigate the effect of confinement on self-assembly, and find that elongated fibers-similar to open-space ones-can be obtained in hard confinement domains but cannot be formed within compliant red blood cell (RBC) domains under the same assumptions. We show, however, that by placing explicitly HbS fibers inside the RBCs and subjecting them to linear elongation and bending, we obtain different types of sickle-shaped RBCs as observed in sickle cell anemia.
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